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Evaluierung eines Modellsystems unter Nutzung der Thy–1/Thy–1 – Ligand Interaktion zur Testung anti – inflammatorischer Substanzen

Schubert K., Polte T., Bönisch U., Schader S., Holtappels R., Hildebrandt G., Lehmann J., Simon J.C., Anderegg U., Saalbach A. Thy-1 (CD90) regulates the extravasation of leukocytes during inflammation. Eur. J. Immunol. 41, 2011; 645-656 / Saalbach A, Haustein UF, and Anderegg U. A ligand of human Thy-1 is localized on polymorphonuclear leukocytes and monocytes and mediates the binding to activated Thy-1 positive microvascular endothelial cells and fibroblasts. J. Invest. Dermatol. 2000; 115: 882-888 / Wetzel A., Wetzig T., Haustein U.F., Sticherling M., Anderegg U., Simon J.C., Saalbach A. Increased Neutrophil Adherence in Psoriasis: Role of the Human Endothelial Cell Receptor Thy-1 (CD90). Journal of Investigative Dermatology. 2006; 126: 441–452 / Saalbach A., Arnhold J., Leßig J., Simon J. C., Anderegg U. Human Thy-1 induces secretion of matrixmetalloproteinase-9 and CXCL8 from human neutrophils. Eur. J. Immunol. 2008; 38: 1391–1403 / Schmidt M., Gutknecht D., Simon J.C., Schulz J.N., Eckes B., Anderegg U., Saalbach A. Controlling the Balance of Fibroblast Proliferation and Differentiation: Impact of Thy-1. J Invest Dermatol. 2015; 135(7):1893-902 / Saalbach, A., Wetzig, T., Haustein, U.F., and Anderegg, U. Detection of human soluble Thy-1 in serum by ELISA: fibroblasts and activated endothelial cells are a possible source of soluble Thy-1 in serum. Cell Tiss. Res. 1999; 298: 307-315 / Wetzel A, Chavakis T, Preissner K, Sticherling M, Haustein U-F, Anderegg U, Saalbach A. Human Thy-1 (CD90) on Activated Endothel Cells is a Counterreceptor for the Leucocyte Integrin Mac-1 (CD11b/CD18). The Journal of Immunology 2004; 172: 3850-3859

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-216709
Date23 December 2016
CreatorsMolkenthin, geb. Schubert, Claudia
ContributorsMedizinischen Fakultät, Klinik für Dermatologie, Venerologie und Allergologie, Prof. Dr. med. habil. Uwe – Frithjof Haustein, Dr. rer. nat. habil. Anja Saalbach, Prof. Dr. rer. nat. Tilo Pompe, Dr. rer. nat. habil. Ulf Anderegg
PublisherUniversitätsbibliothek Leipzig
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
Languagedeu
Detected LanguageEnglish
Typedoc-type:doctoralThesis
Formatapplication/pdf

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