Transposable elements (TEs) are found in nearly all eukaryotic genomes and are a major driving force of genome evolution. The hAT superfamily of TEs are found in a variety of organisms, including plants, fungi, insects and animals. To date, only 14 hAT TEs in the Aedes aegypti genome have been annotated as having a hAT transposase coding sequence. In this study, extensive bioinformatic approaches have been employed to find hAT TEs that encode transposases in the A. aegypti genome. A total of six newly-identified TEs belonging to the hAT superfamily were discovered in the A. aegypti genome. Furthermore, a computer program called TE Displayer was developed to analyze TEs in genome sequences. TE Displayer detects TE-derived polymorphisms in genome datasets and presents the results on a virtual gel image. TE Displayer enables researchers to compare TE profiles in silico and provides a reference profile for experimental analyses.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/31410 |
| Date | 19 December 2011 |
| Creators | Rooke, Rebecca |
| Contributors | Yang, Guojun |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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