Cancer remains the second most common cause of death worldwide affecting around 10
million patients every year. Among the therapeutic options, chemotherapeutic drugs are
widely used but often associated with side effects. In addition, toxicity against immune
cells may hamper anti-tumor immune responses. Some chemotherapeutic drugs,
however, preserve immune functions and some can even stimulate anti-tumor immune
responses through the induction of immunogenic cell death (ICD) rather than apoptosis.
ICD stimulates the immune system by several mechanisms including the release of
damage-associated molecular patterns (DAMPs) from dying cells. In this review, we will
discuss the consequences of inducing two recently characterized forms of ICD, i.e.,
pyroptosis and necroptosis, in the tumor microenvironment (TME) and the perspectives
they may offer to increase the immunogenicity of the so-called cold tumors and to
stimulate effective anti-tumor immune responses.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84396 |
| Date | 30 March 2023 |
| Creators | Scarpitta, Allan, Hacker, Ulrich T., Büning, Hildegard, Boyer, Olivier, Adriouch, Sahil |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2234-943X, 731598 |
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