Yes / Twin-screw granulation has emerged as a key process in powder processing industries and
in the pharmaceutical sector to produce granules with controlled properties. This comprehensive
review provides an overview of the simulation techniques and approaches that have been employed
in the study of twin-screw granulation processes. This review discusses the major aspects of the
twin-screw granulation process which include the fundamental principles of twin-screw granulation,
equipment design, process parameters, and simulation methodologies. It highlights the importance
of operating conditions and formulation designs in powder flow dynamics, mixing behaviour, and
particle interactions within the twin-screw granulator for enhancing product quality and process
efficiency. Simulation techniques such as the population balance model (PBM), computational
fluid dynamics (CFD), the discrete element method (DEM), process modelling software (PMS), and
other coupled techniques are critically discussed with a focus on simulating twin-screw granulation
processes. This paper examines the challenges and limitations associated with each simulation
approach and provides insights into future research directions. Overall, this article serves as a valuable
resource for researchers who intend to develop their understanding of twin-screw granulation and
provides insights into the various techniques and approaches available for simulating the twin-screw
granulation process.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/19997 |
| Date | 02 September 2024 |
| Creators | Arthur, Tony B., Rahmanian, Nejat |
| Source Sets | Bradford Scholars |
| Language | English, English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)., CC-BY |
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