Thesis (MNutr)--Stellenbosch University, 2013. / ENGLISH ABSTRACT: The possible advantages of vitamin D supplementation on various cardiometabolic conditions
have been examined over the past few years. Vitamin D supplementation has possibly shown
effects on each of the individual components of the metabolic syndrome i.e.: obesity,
hypertension, dyslipidaemia and glucose intolerance. The aim of this systematic review was to
ascertain whether or not vitamin D supplementation has any effect on any of the components
of the metabolic syndrome. We searched the (Cochrane Central Register of Controlled Trails
(Central), Medline, Science direct, ISI Web of knowledge and Scopus during 2010 (repeated
search in 2012). We found four randomized controlled trials that met our inclusion and
exclusion criteria. Three hundred and seventy three patients were included in these four
randomized controlled trails comparing vitamin D supplementation with placebo. Duration of
treatment was a minimum of 4 weeks, through to a maximum of on-year. The different trials
looked at various components of the metabolic syndrome as outcomes. The results were not
consistent amongst the trials and the results could not be combined in a meta-analysis due to
heterogeneity in study design and outcomes measured. The current systematic review
highlights the shortcomings in the published data and we recommend further trials be
undertaken before vitamin D supplementation can be recommended as beneficial for patients
with the metabolic syndrome. / AFRIKAANSE OPSOMMING: Die moontlike voordele van vitamien D-aanvullings op verskillende kardiometaboliese
toestande is oor die afgelope paar jaar ondersoek. Daar is aangetoon dat vitamien Daanvullings
uitwerkings het op elk van die individuele komponente van die metaboliese
sindroom naamlik vetsug, hipertensie, dislipidemie en glukose-intoleransie. Die doel van hierdie
sistematiese oorsig was om vas te stel of vitamien D-aanvullings enige uitwerking het op enige
van die komponente van die metaboliese sindroom of nie. Ons het gedurende 2010 soektogte
uitgevoer op die Cochrane Sentrale register van gekontroleerde proewe (Central), Medline,
Science Direct, ISI Web of Knowledge en Scopus (soektog is in 2012 herhaal). Ons het vier
verewekansigde gekontroleerde proewe wat aan ons insluiting- en uitsluitingskriteria voldoen
het, opgespoor. Driehonderd drie en sewentig pasiënte is by die vier proewe ingesluit. Al vier
proewe het vitamien D-aanvullings met plasebo vergelyk. Die duur van behandeling het van 4
weke tot een jaar gestrek. Die verskillende proewe het gekyk na verskillende komponente van
die metaboliese sindroom as uitkomste. Die resultate van die onderskeie proewe was nie
konsekwent nie. Die huidige sistematiese oorsig belig die tekortkominge in die gepubliseerde
data en ons beveel aan dat verdere proewe onderneem word om vas te stel of dit nuttig is om
vitamien D aanvullings vir pasiënte met die metaboliese sindroom aan te beveel, en of dit dalk
skadelik kan wees.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:sun/oai:scholar.sun.ac.za:10019.1/80088 |
| Date | 03 1900 |
| Creators | Wolberg, Charlene |
| Contributors | Herselman, M. G., Hough, F. S., Musekiwa, A., Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Interdisciplinary Health Sciences. Human Nutrition. |
| Publisher | Stellenbosch : Stellenbosch University |
| Source Sets | South African National ETD Portal |
| Detected Language | English |
| Type | Thesis |
| Format | 96 p. |
| Rights | Stellenbosch University |
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