Primary glioblastoma (GBM), IDH-wildtype, especially with multifocal appearance/growth
(mGBM), is associated with very poor prognosis. Several clinical parameters have been identified
to provide prognostic value in both unifocal GBM (uGBM) and mGBM, but information about the
influence of radiological parameters on survival for mGBM cohorts is scarce. This study evaluated
the prognostic value of several volumetric parameters derived from magnetic resonance imaging
(MRI). Data from the Department of Neurosurgery, Leipzig University Hospital, were retrospectively
analyzed. Patients treated between 2014 and 2019, aged older than 18 years and with adequate
peri-operative MRI were included. Volumetric assessment was performed manually. One hundred
and eighty-three patients were included. Survival of patients with mGBM was significantly shorter
(p < 0.0001). Univariate analysis revealed extent of resection, adjuvant therapy regimen, residual
tumor volume, tumor necrosis volume and ratio of tumor necrosis to initial volume as statistically
significant for overall survival. In multivariate Cox regression, however, only EOR (for uGBM and
the entire cohort) and adjuvant therapy were independently significant for survival. Decreased ratio
of tumor necrosis to initial tumor volume and extent of resection were associated with prolonged
survival in mGBM but failed to achieve statistical significance in multivariate analysis.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89154 |
| Date | 19 January 2024 |
| Creators | Kasper, Johannes, Hilbert, Nicole, Wende, Tim, Fehrenbach, Michael Karl, Wilhelmy, Florian, Jähne, Katja, Frydrychowicz, Clara, Hamerla, Gordian, Meixensberger, Jürgen, Arlt, Felix |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 10.3390/curroncol28020136 |
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