Background: Obesity-associated metabolic complications display sexual
dimorphism and can be impacted by cytokines. We previously showed that
interleukin-10 (IL-10) was upregulated in white adipose tissue (WAT) of obese
women with type 2 diabetes (T2D). Whether this pertains to men is unknown.
The aim of this study was to compare the impact of obesity and T2D on WAT IL-
10 levels in men versus women.
Methods: Plasma and subcutaneous WAT biopsies were obtained from 108
metabolically well-characterized individuals. WAT IL10 expression/secretion and
WAT-resident IL-10-secreting macrophage number were measured. Circulating
sex hormone levels were correlated toWAT IL10 expression in 22 individuals and sex
hormone effects on macrophage IL10 expression were investigated in vitro.
Results: Obese women with T2D showed increased IL10 expression/secretion and
IL-10-secreting WAT macrophage number compared to other female groups. This
difference was absent in men. Non-obese women and men with T2D showed
similar IL-10 levels compared to healthy controls, indicating that T2D alone does not
regulate IL-10. Although WAT IL10 expression correlated with serum estrone (E1)
concentrations, recombinant E1 did not affect macrophage IL10 expression in vitro.
Conclusion: WAT IL-10 levels are higher in women with obesity and T2D, but
not in men and this effect is primarily attributed to obesity per se. This is less
likely to be driven by circulating sex hormones. We propose that the WAT IL-10
might exert protective effects in obesity-associated chronic inflammation in
women which could be one of the contributing factors for the decreased
morbidity observed in women during obesity than men.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:90259 |
| Date | 29 February 2024 |
| Creators | Subramanian, Narmadha, Tavira, Beatriz, Hofwimmer, Kaisa, Gutsmann, Beate, Massier, Lucas, Abildgaard, Julie, Juul, Anders, Ryden, Mikael, Arner, Peter, Laurencikiene, Jurga |
| Publisher | Frontiers Media S.A. |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 996954 |
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