Insights into the modes of action (MoAs) of xenobiotics are of utmost importance for
the definition of adverse outcome pathways (AOPs), which are essential for a mechanism-based risk
assessment. A well-established strategy to reveal MoAs of xenobiotics is the use of omics. However,
often an even more comprehensive approach is needed, which can be achieved using multi-omics.
Since the immune system plays a central role in the defense against foreign substances and pathogens,
with the innate immune system building a first barrier, we systematically reviewed multi-omics
studies investigating the effects of xenobiotics on macrophages. Surprisingly, only nine publications
were identified, combining proteomics with transcriptomics or metabolomics. We summarized
pathways and single proteins, transcripts, or metabolites, which were described to be affected upon
treatment with xenobiotics in the reviewed studies, thus revealing a broad range of effects. In summary,
we show that macrophages are a relevant model system to investigate the toxicological effects induced
by xenobiotics. Furthermore, the multi-omics approaches led to a more comprehensive overview
compared to only one omics layer with slight advantages for combinations that complement each
other directly, e.g., proteome and metabolome.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89565 |
| Date | 07 February 2024 |
| Creators | Karkossa, Isabel, Raps, Stefanie, von Bergen, Martin, Schubert, Kristin |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 9371 |
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