(1) Adipsin is an adipokine that may link increased fat mass and adipose tissue dysfunction
to obesity-related cardiometabolic diseases. Here, we investigated whether adipsin serum concentrations
and adipose tissue (AT) adipsin mRNA expression are related to parameters of AT function,
obesity and type 2 diabetes (T2D). (2) Methods: A cohort of 637 individuals with a wide range of
age and body weight (Age: 18–85 years; BMI: 19–70 kg/m2) with (n = 237) or without (n = 400) T2D
was analyzed for serum adipsin concentrations by ELISA and visceral (VAT) and subcutaneous (SAT)
adipsin mRNA expression by RT-PCR. (3) Results: Adipsin serum concentrations were significantly
higher in patients with T2D compared to normoglycemic individuals. We found significant positive
univariate relationships of adipsin serum concentrations with age (r = 0.282, p < 0.001), body weight
(r = 0.264, p < 0.001), fasting plasma glucose (r = 0.136, p = 0.006) and leptin serum concentrations
(r = 0.362, p < 0.001). Neither VAT nor SAT adipsin mRNA expression correlated with adipsin serum
concentrations after adjusting for age, sex and BMI. Independent of T2D status, we found significantly
higher adipsin expression in SAT compared to VAT (4) Conclusions: Our data suggest that adipsin
serum concentrations are strongly related to obesity and age. However, neither circulating adipsin
nor adipsin AT expression reflects parameters of impaired glucose or lipid metabolism in patients
with obesity with or without T2D.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:90109 |
| Date | 22 February 2024 |
| Creators | Milek, Margarete, Moulla, Yusef, Kern, Matthias, Stroh, Christine, Dietrich, Arne, Schön, Michael R., Gärtner, Daniel, Lohmann, Tobias, Dressler, Miriam, Kovacs, Peter, Stumvoll, Michael, Blüher, Matthias, Guiu-Jurado, Esther |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2222 |
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