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Biconditional discrimination learning in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis

The experiment tested the hypothesis that 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) in rats would impair performance in a biconditional visual discrimination task, which requires configural association learning. Experiment used 22 male Long-Evan rats (Harlan Sprague-Dawley). Behavioral testing was conducted in two identical T-mazes. Rats were randomly assigned to either a bilateral 192 IgG-saporin lesion group (n = 10) or to a control group (n = 12). Results support the hypothesis that NBM is critically involved in configural but not simple association learning and suggest that NBM may be involved more generally in cognitive flexibility.

Identiferoai:union.ndltd.org:csusb.edu/oai:scholarworks.lib.csusb.edu:etd-project-4019
Date01 January 2006
CreatorsKitto, Michael Ryan
PublisherCSUSB ScholarWorks
Source SetsCalifornia State University San Bernardino
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceTheses Digitization Project

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