Background: Dietary and serum antioxidants and physical activity can effect inflammation, which is associated with breast cancer risk and recurrence. This study investigated the relationship between diet, serum antioxidant capacity, physical activity, and inflammation in breast cancer survivors and individuals without cancer.
Methods: Existing demographic, dietary intake, and physical activity data of 78 breast cancer survivors and 30 individuals without cancer from the Day and Night Study conducted at Virginia Commonwealth University were used. Participants were recruited from southern Virginia. Metabolic equivalents were calculated through type, intensity, and duration of physical activity. Dietary antioxidant intake (FRAP) was calculated from Harvard Food Frequency Questionnaire data. Serum samples were analyzed for inflammation (hsCRP,IL-6,IL-1,and TNF alpha) and serum antioxidant capacity (ORAC) at Virginia Tech.
Results: Anthropometrics and inflammation were higher, and FRAP and ORAC lower in breast cancer survivors compared to individuals without cancer, although not significant. There was a significant direct relationship between FRAP and ORAC and inverse relationship between FRAP and hsCRP. Breast cancer survivors 6+ years since diagnosis showed significant direct FRAP and IL-1 association, and inverse ORAC and TNF-alpha association. BMI was directly associated with IL-6 and CRP. Inflammation was not associated with METs or weekly activity, although there was an increasing inverse relation between METs, IL-1 and TNF- α with increasing ORAC.
Conclusion: There is a significant relationship between dietary antioxidant intake and serum antioxidant capacity and inflammation. Increased body mass index increases inflammation. Diets high in antioxidants and maintaining a healthy weight may help reduce inflammation in breast cancer survivors. / Master of Science / Background: Dietary and serum antioxidants and physical activity can effect inflammation, which is associated with breast cancer risk and recurrence. This study investigates the relationship between diet, serum antioxidant capacity, physical activity, and inflammation in breast cancer survivors and individuals without cancer.
Methods: Demographic, dietary intake, and physical activity data of 78 breast cancer survivors and 30 individuals without cancer from the Day and Night Study conducted at Virginia Commonwealth University were used. Participants were recruited in southern Virginia. Metabolic equivalents, a measure of physical activity, were calculated from type, intensity, and duration of physical activity. Dietary antioxidant intake (FRAP) was calculated from Harvard Food Frequency Questionnaire data. Serum samples were analyzed for inflammation (hsCRP, IL-6, IL-1, and TNF-alpha) and serum antioxidant capacity (ORAC) at Virginia Tech.
Results: Anthropometrics and inflammation were higher in breast cancer survivors while FRAP and ORAC were lower. Significance existed between dietary antioxidant intake and serum antioxidant capacity as well as dietary antioxidant intake and hsCRP. Higher body mass index was associated with increased inflammation. Breast cancer survivors 6+ years since diagnosis with higher dietary antioxidant intake had lower IL-1, and with serum antioxidant capacity and TNF-alpha.
Conclusion: In this population there is a significant relationship between dietary and serum antioxidant capacity, as well as dietary antioxidant capacity and hsCRP. In breast cancer survivors 6+ years since diagnosis there are significant associations in antioxidant capacity and inflammation. This is evidence that dietary antioxidants and maintaining a healthy weight can help reduce inflammation.
| Identifer | oai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/83842 |
| Date | 02 July 2018 |
| Creators | Mozhi, Dimple Aneka |
| Contributors | Human Nutrition, Foods, and Exercise, Rafie, Carlin, Ju, Young Hwa, Schmelz, Eva M., Van Mullekom, Jennifer H. |
| Publisher | Virginia Tech |
| Source Sets | Virginia Tech Theses and Dissertation |
| Detected Language | English |
| Type | Thesis |
| Format | ETD, application/pdf, application/pdf |
| Rights | In Copyright, http://rightsstatements.org/vocab/InC/1.0/ |
Page generated in 0.0022 seconds