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Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats

Background: Arterial allografts are used as vascular conduits in the treatment of prosthetic graft infection. Immunosuppression
decreases their rupture risk rate. However, immunosuppression can be unprofitable in florid infection. Previously, we confirmed inhibition of cell-mediated destruction of rat aortic grafts by delayed use of tacrolimus. In this work, we studied the influence of this protocol on the antibody-mediated rejection.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-167365
Date12 May 2014
CreatorsMatia, Ivan, Fellmer, Peter, Splith, Katrin, Varga, Martin, Adamec, Milos, Kämmerer, Ines, Feldbrügge, Linda, Krenzien, Felix, Hau, Hans-Michael, Atanasov, Georgi, Schmelzle, Moritz, Jonas, Sven
ContributorsUniversitätsklinikum Leipzig, Klinik für Viszeral-, Transplantations-, Thorax- und Gefäßchirurgie, Universitätsklinikum Leipzig, Translationszentrum für Regenerative Medizin, Institute for Clinical and Experimental Medicine, Transplant Surgery Department, Annals of transplantation,
PublisherUniversitätsbibliothek Leipzig
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typedoc-type:article
Formatapplication/pdf
SourceAnnals of transplantation 2014, 19:225-232

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