Investigations of the interactions of benzylpenicilloic acid with human erythrocytes ; and, RCHDCHDX compounds as stereochemical probes : MINDO/3 and MNDO investigations of conformational preferences in RCHb2sCHb2sX compounds / Investigations of the interactions of benzylpenicilloic acid with human erythrocytes. / RCHDCHDX compounds as stereochemical probes.

Description

Benzylpenicillin was found to migrate irreversibly into human erythrocytes. No detectable amounts of penicillin bind to the erythrocyte membrane. After migration into the cell, benzylpenicillin is hydrolyzed into benzylpenicilloic acid, which can not migrate out of the cell. DNDS did not affect the appearance of benzylpenicilloic acid in the erythrocyte, therefore showing that: 1) benzylpenicillin does not hydrolyze to benzylpenicilloic acid in the incubation mixture then migrate to the cell, 2) benzylpenicillin migrates into the erythrocyte and is hydrolyzed to benzylpenicilloic acid. Benzylpenicilloic acid does not migrate into erythrocytes.Ball State UniversityMuncie, IN 47306

Links & Downloads

1. LD2489.Z78 1982 .W53
2. http://cardinalscholar.bsu.edu/handle/handle/182523
3. http://liblink.bsu.edu/uhtbin/catkey/388165

Tags

Penicillin -- Physiological effect.

Stereochemistry.

Ball State University. Thesis (M.S.)

Additional Fields

Identifer	oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/182523
Date	03 June 2011
Creators	Wihebrink, W. Scott
Contributors	Wihebrink, W. Scott. RCHDCHDX compounds as stereochemical probes., Wagner, Eugene S.
Source Sets	Ball State University
Detected Language	English
Format	x, 79 leaves : ill. ; 28 cm.
Source	Virtual Press