The bony fin rays of the zebrafish caudal fin are a convenient system for studying bone morphogenesis and patterning. Joints and bifurcations in fin rays follow predictable spatial patterns, though the mechanisms underlying these patterns are not well understood. We developed simulation models to explore ray pattern formation mechanisms in growing fins. In all models, the fin ray growth rates are based on quantitative experimental data. The different models simulate ray joint formation and bifurcation formation using different hypothetical mechanisms. In the most plausible model, ray joint and bifurcation formation result from the accumulation of two substances, arbitrarily named J and B. Model parameters were optimized to find the best fit between model output and quantitative experimental data on fin ray patterns. The model will be tested in the future by evaluating how well it can predict fin ray patterns in different fin shapes, mutant zebrafish fins, and other fish species.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OOU.#10393/23181 |
| Date | 22 August 2012 |
| Creators | Tweedle, Valerie |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Thèse / Thesis |
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