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CMOS Transimpedance Amplifier for Biosensor Signal Acquisition

A 1-G?? CMOS transimpedance amplifier (TIA) suitable for processing sub-nA-level currents in electrochemical biosensor signal-acquisition circuits is presented. Use of a two-stage active transconductor provides resistive feedback in place of a large-area linear resistor. The TIA feedback loop is engineered to suppress output offset caused by DC input leakage currents of ??0.9 nA. A mechanism to tune the low-frequency cutoff of the TIA from 0.7 Hz to 500 Hz is implemented which permits operation under variable environmental conditions. Simulated and experimental results from a custom TIA fabricated in a 3.3-V 0.35-??m CMOS process are presented.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OWTU.10012/8147
Date20 January 2015
CreatorsIbrahim, Mark
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation

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