Introducción: El cáncer de mama es la neoplasia más frecuente en el mundo y las mujeres jóvenes representan el 11,6% de los casos. En el Perú existen pocos estudios que evalúen cáncer en este grupo poblacional. Nuestro objetivo es analizar la sobrevida libre de enfermedad (SLE) y sobrevida global (SG) a los cinco años en mujeres <36 años.
Métodos: Cohorte retrospectiva de mujeres <36 años con adenocarcinoma mamario atendidas en el Instituto Nacional de Enfermedades Neoplásicas 2010–2014. Características demográficas y clínicas fueron recolectadas de la historia clínica. Se estimó SLE y SG al año y cinco años, se realizaron curvas de Kaplan-Meier comparadas mediante Log Rank, y se calcularon Hazard ratios (HR) crudos y ajustados mediante regresión de Cox.
Resultados: Se incluyeron 346 mujeres en el análisis de SG, y 211 para SLE. La SLE a los cinco años fue 57% (48-65%), la SG 51% (46-57%). Menor edad (HR 1,12; 1,03-1,22), mayor tamaño tumoral (HR 1,11; 1,04-1,18) y subtipo Luminal B (HR 2,22; 1,04-4,76) se asociaron a recurrencia. Menor edad (HR 1,08; 1,01-1,14), mayor tamaño tumoral (HR 1,14; 1,08-1,20), estadio clínico III (HR 2,05; 1,03-4,08), subtipo triple negativo (HR 1,81; 1,01-3,23), no cirugía (HR 6,53; 3,71-11,5), y quimioterapia adyuvante sola (HR 1,97; 1,09-3,56) se asociaron a muerte. Tener familiares con cáncer de mama resultó protector para muerte (HR 0,49; 0,26-0,92).
Conclusión: La SLE y SG fueron más bajas que las reportadas previamente. Menor edad, mayor tamaño tumoral y subtipo Luminal B se asociaron a recurrencia. Menor edad, mayor tamaño tumoral, estadio III, subtipo Triple Negativo, no cirugía, y adyuvancia sola se asociaron a mayor riesgo de muerte. / Introduction: Breast cancer is the most frequent neoplasm in the world, and young women represent 11.6% of total cases. There are few studies in Peru addressing cancer in this population. The study goal is to analyze disease free survival (DFS) and overall survival (OS) at five years in women <36 years old.
Methods: Retrospective cohort including women <36 years old with breast adenocarcinoma who attended the Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru 2010–2014. Demographic and clinical characteristics were collected form medical charts. DFS and OS were estimated at one and five years. Kaplan-Meier curves were elaborated and compared using Log Rank test. Crude and adjusted Hazard ratios (HR) were obtained using Cox regression.
Results: We included 346 women in the OS analysis, and 211 in the DFS analysis. Five-year DFS was 57% (48-65%) and five-year OS was 51% (46-57%). Younger age (HR 1.12; 1.03-1.22), bigger tumor size (HR 1.11; 1.04-1.18) and Luminal B subtype (HR 2.22; 1.04-4.76) were associated to recurrence. Younger age (HR 1.08; 1.01-1.14), bigger tumor size (HR 1.14; 1.08-1.20), clinical stage III (HR 2.05; 1.03-4.08), triple negative subtype (HR 1.81; 1.01-3.23), no surgery (HR 6.53; 3.71-11.5), and adyuvancy alone (HR 1.97; 1.09-3.56) were associated to higher risk of death. Having family with breast cancer was protective for death (HR 0.49; 0.26-0.92).
Conclusion: DFS and OS were lower than reported in other parts of the world. Younger age, bigger tumor size and Luminal B subtype were associated to recurrence. Younger age, bigger tumor size, clinical stage III, triple negative subtype, no surgery and receiving adyuvancy alone were associated to higher risk of death. / Tesis
| Identifer | oai:union.ndltd.org:PERUUPC/oai:repositorioacademico.upc.edu.pe:10757/648793 |
| Date | 09 December 2019 |
| Creators | Valiente Borrero, Daniela Fernanda, Coico Sierra, Rodrigo Alexander |
| Contributors | Araujo Castillo, Roger V, Morante, Zaida, Neciosup, Silvia |
| Publisher | Universidad Peruana de Ciencias Aplicadas (UPC) |
| Source Sets | Universidad Peruana de Ciencias Aplicadas (UPC) |
| Language | Spanish |
| Detected Language | Spanish |
| Type | info:eu-repo/semantics/bachelorThesis |
| Format | application/pdf, application/msword |
| Source | Universidad Peruana de Ciencias Aplicadas (UPC), Repositorio Académico - UPC |
| Rights | info:eu-repo/semantics/openAccess, Attribution-NonCommercial-ShareAlike 4.0 International, http://creativecommons.org/licenses/by-nc-sa/4.0/ |
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