Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.

Description

The laminin-binding integrin (LBI) family are cell adhesion molecules that are essential for invasion and metastasis of human epithelial cancers and cell adhesion mediated drug resistance. We investigated whether copy number alteration (CNA) or mutations of a five-gene signature (ITGB4, ITGA3, LAMB3, PLEC, and SYNE3), representing essential genes for LBI adhesion, would correlate with patient outcomes within human epithelial-type tumor data sets currently available in an open access format.

Links & Downloads

1. Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. 2016, 8 (2):940-54 Am J Transl Res
2. 1943-8141
3. 27158381
4. http://hdl.handle.net/10150/615112
5. http://arizona.openrepository.com/arizona/handle/10150/615112
6. American journal of translational research

Tags

Cancer

gene copy

laminin

integrin

cBioPortal

copy number alterations

Additional Fields

Identifer	oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/615112
Date	January 2016
Creators	Harryman, William L, Pond, Erika, Singh, Parminder, Little, Andrew S, Eschbacher, Jennifer M, Nagle, Raymond B, Cress, Anne E
Contributors	Univ Arizona, Ctr Canc
Publisher	E-CENTURY PUBLISHING CORP
Source Sets	University of Arizona
Language	English
Detected Language	English
Type	Article
Rights	Creative Commons Attribution Non-Commercial License
Relation	http://www.ajtr.org/files/ajtr0019463.pdf