Yes / The development of androgenetic alopecia is associated
with a risk of developing cardiovascular diseases,
but the association of alopecia areata with cardiovascular
diseases in humans is largely unexplored. We
measured the plasma level of two common cardiovascular
disease markers, cardiac troponin I and Creactive
protein, in alopecia areata and androgenetic
alopecia-affected subjects. Also, we investigated the
possible presence of pro-apoptotic factors in the plasma
of hair loss subjects. The mean plasma cardiac troponin
I level was highest in alopecia areata subjects,
moderately higher in androgenetic alopecia subjects,
and lowest in subjects without hair loss (p < 0.05).
Alopecia areata subjects not receiving treatments had
highest levels of cardiac troponin I (p < 0.05). Alopecia
areata plasma samples with high cardiac troponin I
levels also induced significantly higher rates of cardiomyocyte
apoptosis in cell culture assays. The results
suggest the potential for increased heart remodelling.
Close monitoring of cardiovascular health in alopecia
areata subjects, as well as subsets of androgenetic
alopecia patients, may be appropriate. / Canadian Institutes of Health Research (CIHR; MOP-82927). EW is the recipient of a Banting Postdoctoral Fellowship (SAC-92845).
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/16565 |
| Date | 08 May 2018 |
| Creators | Wang, E.H.C., Santos, L., Li, X.Y., Tran, A., Kim, S.S.Y., Woo, K., Shapiro, J., McElwee, Kevin J. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | © 2018 Acta Dermato-Venereologica. Reproduced in accordance with the publisher's self-archiving policy. This is an open access article under the CC BY-NC license., CC-BY-NC |
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