Previous studies showed that memantine inhibits tau hyperphosphorylation in vitro. In this study, phosphorylated tau (P-tau) and total tau (T-tau) were measured before and after 6 month treatment with memantine in 12 subjects ranging from normal cognition with subjective memory complaints, through mild cognitive impairment to mild Alzheimer's disease. Thirteen non-treated individuals served as controls. Treatment was associated with a reduction of P-tau in subjects with normal cognition. No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group.
| Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-18552 |
| Date | 01 January 2009 |
| Creators | Glodzik, Lidia, De Santi, Susan, Rich, Kenneth E., Brys, Miroslaw, Pirraglia, Elizabeth, Mistur, Rachel, Switalski, Remigiusz, Mosconi, Lisa, Sadowski, Martin, Zetterberg, Henrik, Blennow, Kaj, De Leon, Mony J. |
| Publisher | Digital Commons @ East Tennessee State University |
| Source Sets | East Tennessee State University |
| Detected Language | English |
| Type | text |
| Source | ETSU Faculty Works |
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