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Synthesis of Trachelanthamidine, Supinidine and the core of stenine

Base-induced coupling-cyclization stepwise [3+2] annulation of
£\-sulfonylacetamide with (Z)-2-bromoacrylate yielded the polysubsti-
tuted pyroglutamate with three contiguous chiral centers with trans-
trans orientation in a one-pot synthesis. The pyrrolizidine skeleton and
the core of stenine were obtained via the ring-closing metathesis (RCM)
method.This facile strategy was used to synthesize (¡Ó)-trachelantha-
midine, (¡Ó)-supinidine and the core of stenine.

Identiferoai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0717106-152456
Date17 July 2006
CreatorsWu, Dong-Ciao
ContributorsNein-Chen Chang, Chin-Hsing Chou, Meng-Yang Chang, Cherng-Chyi Tzeng
PublisherNSYSU
Source SetsNSYSU Electronic Thesis and Dissertation Archive
LanguageCholon
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717106-152456
Rightsrestricted, Copyright information available at source archive

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