Base-induced coupling-cyclization stepwise [3+2] annulation of
£\-sulfonylacetamide with (Z)-2-bromoacrylate yielded the polysubsti-
tuted pyroglutamate with three contiguous chiral centers with trans-
trans orientation in a one-pot synthesis. The pyrrolizidine skeleton and
the core of stenine were obtained via the ring-closing metathesis (RCM)
method.This facile strategy was used to synthesize (¡Ó)-trachelantha-
midine, (¡Ó)-supinidine and the core of stenine.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0717106-152456 |
| Date | 17 July 2006 |
| Creators | Wu, Dong-Ciao |
| Contributors | Nein-Chen Chang, Chin-Hsing Chou, Meng-Yang Chang, Cherng-Chyi Tzeng |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717106-152456 |
| Rights | restricted, Copyright information available at source archive |
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