Global ETD Search

1	Synthetic studies toward 3,4,5-trisubstituted-piperidine and cis-4-substituted-5-amino-£_-lactam HsieH, Tai-ran 24 June 2004 (has links) none pyroglutamate piperidine lactam
2	Synthetic Studies Toward Kainic acid and Lycorane Liu, Yen-ting 04 July 2007 (has links) We have developed an one-pot reaction procedure to polysubstituted pyroglutamates with three contiguous chiral centers. The results were applied to the synthetic studies toward kainic acid and lycorane. pyroglutamate [3+2] annulation kainic acid lycorane
3	Synthesis of Trachelanthamidine, Supinidine and the core of stenine Wu, Dong-Ciao 17 July 2006 (has links) Base-induced coupling-cyclization stepwise [3+2] annulation of £\-sulfonylacetamide with (Z)-2-bromoacrylate yielded the polysubsti- tuted pyroglutamate with three contiguous chiral centers with trans- trans orientation in a one-pot synthesis. The pyrrolizidine skeleton and the core of stenine were obtained via the ring-closing metathesis (RCM) method.This facile strategy was used to synthesize (¡Ó)-trachelantha- midine, (¡Ó)-supinidine and the core of stenine. the core of stenine supinidine ring closing metathesis trachelanthamidine pyroglutamate
4	Synthetic Studies of Polysubstituted Pyroglutamates and Its Applications in Natural Products Synthesis Sun, Pei-Pei 03 July 2003 (has links) We have explored a formal [3+2] strategy that is synthetically useful for constructing polysubstituted pyroglutamates with three contiguous chiral centers in one step. Base-induced coupling/cyclization reactions of a-sulfonylacetamide with various ethyl (Z)-2-bromo-2-propenoates have been carried out. This reaction with high diastereoselectivity has been applied to the synthesis of Rolipram, Chlorpheg, Baclofen, Pseudoheliotridane and Kainic acid. baclofen chlorpheg [3+2]cycloaddition pseudoheliotridane pyroglutamate rolipram kainic acid
5	1. Synthetic Study of Pyrrolizidine Skeleton 2. Synthetic Study Toward Tylophorine and Cryptopleurine 3. Synthetic Study of Fused Bicyclic Glutarimides Hsu, Ru-Ting 18 January 2005 (has links) Reaction of 3-sulfonyl acetamides with various substituted methyl acrylate derivatives furnished pyroglutamate and glutarimidess via [3+2] and [3+3] cycloaddition respectively. The results were applied to the synthesis of pyrrolizidine skeleton, tylophorine, cryptopleurine and fused bicyclic glutarimides. [3+2] annulation pyroglutamate pyrrolizidine fused bicyclic [3+3] annulation quinolizidine ring-closing metathesis
6	The role of N-truncated Aβ peptides in Alzheimer’s Disease Lopez Noguerola, Jose Socrates 26 June 2018 (has links) No description available. 570 Alzheimer’s disease N-truncated Aβ Pyroglutamate Aβ Neuron loss Intraneuronal Aβ Biologie (PPN619462639)
7	Pyroglutamate-Modified Amyloid β (11- 40) Fibrils Are More Toxic than Wildtype Fibrils but Structurally Very Similar Scheidt, Holger A., Adler, Juliane, Höfling, Corinna, Korn, Alexander, Krueger, Martin, Roßner, Steffen, Huster, Daniel 18 December 2024 (has links) The morphology, structure, and dynamics of mature amyloid β (Aβ) fibrils formed by the Aβ variant, which is truncated at residue 11 and chemically modified by enzymatic pyroglutamate formation (pGlu11-Aβ(11–40)), was studied along with the investigation of the toxicity of these Aβ variants to neurons and astrocytes. The fibrils of pGlu11-Aβ (11–40) were more toxic than wildtype Aβ (1–40) and the longer pGlu3-Aβ (3–40) especially at higher concentration, whereas the overall morphology was quite similar. The secondary structure of pGlu11-Aβ (11–40) fibrils shows the typical two β-strands connected by a short turn as known for mature fibrils of Aβ (1–40) and also pGlu3-Aβ (3–40). Further insights into tertiary contacts exhibit some similarities of pGlu11-Aβ (11–40) fibrils with wildtype Aβ (1–40), but also a so far not described contact between Gly25 and Ile31. This highlights the biological importance of chemical modifications on the molecular structure of Aβ. info:eu-repo/classification/ddc/540 ddc:540
8	Alpha synuclein processing by MMP-3 – implications for synucleinopathies Bluhm, Alexandra, Schrempel, Sarah, Moceri, Sandra, Stieler, Jens, Feja, Malte, Schilling, Stephan, Schulze, Anja, Hörsten, Stephan von, Hartlage-Rübsamen, Maike, Richter, Franziska, Roßner, Steffen 12 November 2024 (has links) No description available.
9	Die Bedeutung des Pyroglutamat-Abeta-Oligomer-Blutplasmaspiegels und des Apolipoprotein-E-Genotyps bei der Alzheimer-Krankheit / The relevance of oligomeric Pyroglutamate-Abeta in blood plasm and the Apolipoprotein-E-Genotype for the Alzheimer's Disease von Waldenfels, Gabriel 04 April 2012 (has links) No description available. 610 Medizin, Gesundheit MED 550 Medicine 44.91
10	Neuropathological and behavioral alterations in two transgenic mouse models of Alzheimer´s disease Meißner, Julius Nicolai 19 July 2016 (has links) No description available. 610 Alzheimer´s disease AD amyloid Abeta pyroglutamate LRP1 5xFAD Morris water maze neurodegeneration behavior dementia Medizin (PPN619874732) Psychiatrie (PPN619876344)

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