Spelling suggestions: "subject:"pyroglutamic""
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Synthetic studies toward 3,4,5-trisubstituted-piperidine and cis-4-substituted-5-amino-£_-lactamHsieH, Tai-ran 24 June 2004 (has links)
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Synthetic Studies Toward Kainic acid and LycoraneLiu, Yen-ting 04 July 2007 (has links)
We have developed an one-pot reaction procedure to polysubstituted pyroglutamates with three contiguous chiral centers. The results were applied to the synthetic studies toward kainic acid and lycorane.
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Synthesis of Trachelanthamidine, Supinidine and the core of stenineWu, Dong-Ciao 17 July 2006 (has links)
Base-induced coupling-cyclization stepwise [3+2] annulation of
£\-sulfonylacetamide with (Z)-2-bromoacrylate yielded the polysubsti-
tuted pyroglutamate with three contiguous chiral centers with trans-
trans orientation in a one-pot synthesis. The pyrrolizidine skeleton and
the core of stenine were obtained via the ring-closing metathesis (RCM)
method.This facile strategy was used to synthesize (¡Ó)-trachelantha-
midine, (¡Ó)-supinidine and the core of stenine.
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Synthetic Studies of Polysubstituted Pyroglutamates and Its Applications in Natural Products SynthesisSun, Pei-Pei 03 July 2003 (has links)
We have explored a formal [3+2] strategy that is synthetically useful for constructing polysubstituted pyroglutamates with three contiguous chiral centers in one step. Base-induced coupling/cyclization reactions of a-sulfonylacetamide with various ethyl (Z)-2-bromo-2-propenoates have been carried out. This reaction with high diastereoselectivity has been applied to the synthesis of Rolipram, Chlorpheg, Baclofen, Pseudoheliotridane and Kainic acid.
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1. Synthetic Study of Pyrrolizidine Skeleton 2. Synthetic Study Toward Tylophorine and Cryptopleurine 3. Synthetic Study of Fused Bicyclic GlutarimidesHsu, Ru-Ting 18 January 2005 (has links)
Reaction of 3-sulfonyl acetamides with various substituted methyl acrylate derivatives furnished pyroglutamate and glutarimidess via [3+2] and [3+3] cycloaddition respectively. The results were applied to the synthesis of pyrrolizidine skeleton, tylophorine, cryptopleurine and fused bicyclic glutarimides.
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The role of N-truncated Aβ peptides in Alzheimer’s DiseaseLopez Noguerola, Jose Socrates 26 June 2018 (has links)
No description available.
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Die Bedeutung des Pyroglutamat-Abeta-Oligomer-Blutplasmaspiegels und des Apolipoprotein-E-Genotyps bei der Alzheimer-Krankheit / The relevance of oligomeric Pyroglutamate-Abeta in blood plasm and the Apolipoprotein-E-Genotype for the Alzheimer's Diseasevon Waldenfels, Gabriel 04 April 2012 (has links)
No description available.
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Neuropathological and behavioral alterations in two transgenic mouse models of Alzheimer´s diseaseMeißner, Julius Nicolai 19 July 2016 (has links)
No description available.
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The contribution of N-terminally modified amyloid beta to the etiology of Alzheimer's diseaseWittnam, Jessica L. 21 May 2012 (has links)
No description available.
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Studies on the Involvement of the Immune system in Alzheimer's diseaseAndrea, Marcello 23 March 2010 (has links)
No description available.
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