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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"pseudohermitian"" "subject:"dihydroxyheliotridane""

1

Synthetic Studies of Polysubstituted Pyroglutamates and Its Applications in Natural Products Synthesis

Sun, Pei-Pei 03 July 2003 (has links)
We have explored a formal [3+2] strategy that is synthetically useful for constructing polysubstituted pyroglutamates with three contiguous chiral centers in one step. Base-induced coupling/cyclization reactions of a-sulfonylacetamide with various ethyl (Z)-2-bromo-2-propenoates have been carried out. This reaction with high diastereoselectivity has been applied to the synthesis of Rolipram, Chlorpheg, Baclofen, Pseudoheliotridane and Kainic acid.
baclofen
chlorpheg
[3+2]cycloaddition
pseudoheliotridane
pyroglutamate
rolipram
kainic acid

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