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Previous issue date: 2011-04-26 / This study was performed at Hospital de Cl?nicas Veterin?rias do Centro Universit?rio
Pl?nio Leite Itabora?, Rio de Janeiro (Veterinary Hospital of Pl?nio Leite University, Itabora?,
Rio de Janeiro) to monitor the hepatic biochemical profile of cats and their clinical parameters
when submitted to continuous infusion of propofol at a 0,3 mg/kg/min dosage, for 90 minutes,
and comparing to results obtained from cats who received continuous infusion of saline
solution. Both groups were analyzed during a pre-determined period of time totalizing 28
days of observation and analysis. The following enzymes activity levels were determined:
Aminotransferase (AST), Alanina-Aminotransferase (ALT), Gamma Glutamyl
Transpeptidase (GGT) and Alkaline Fosfatasis (FA); serum levels of Albumin (A), Total
Bilirrubin (BT) and Total Serum Proteins (PT), yet registering Respiratory (FR) and Heart
Rate (FC), Systolic Blood Pressure (PAS), Mean Arterial Blood Pressure (PAM), Diastolic
Blood Pressure (PAD) and Oxygen Partial Saturation (SPO2). Twenty healthy cats were
analyzed on this study, their weights varying from two to four kilos and ages between three to
five years old, submitted to experimental procedures performed during the months of January
and February, 2010. The analysis of these results showed a major difference (p<0,05) between
the ALT serum activities at the following positions: T2 (30 minutes), T3 (60 minutes), T5 (12
hours) and T9 (28 days); AST serum activities at T2, FA serum activities at T2, T6 (seven
days) and T8 (21 days), emphasizing the fact only at this last position the GP levels were
greater than GC; in the heart rate at T1 position (the beginning of this experiment), without
compromising animals physical condition. None of the animals presented averages above
parameters of normality. The other parameters examined did not present any significant
differences, concluding that total intravenous anesthesia using continuous infusion of
propofol was safe to contain cats in invasive surgical procedures, therefore providing more
information regarding the safe use of this drug in animals. / O trabalho foi desenvolvido no Hospital de Cl?nicas Veterin?rias do Centro
Universit?rio Pl?nio Leite, em Itabora?, RJ, com o intuito de monitorar perfil bioqu?mico
hep?tico e par?metros cl?nicos de gatos submetidos ? infus?o cont?nua de propofol (GP) na
dose de 0,3 mg/kg/min, durante 90 minutos, e comparando-se com resultados observados em
gatos do grupo controle (GC), que receberam infus?o cont?nua de solu??o fisiol?gica. Os dois
grupos foram avaliados em espa?os de tempo pr?-determinados, totalizando 28 dias de
observa??es e an?lises. Foram determinadas as atividades s?ricas de aspartatoaminotransferase
(AST), alanina-aminotransferase (ALT), gama-glutamil transpeptidase
(GGT) e fosfatase alcalina (FA), determinadas as concentra??es s?ricas de Albumina (A),
Bilirrubina total (BT) e Prote?nas Totais s?ricas (PT), registrando-se ainda as Frequ?ncias
Respirat?rias (FR) e Card?acas (FC), Temperatura Retal (T), Press?es Arteriais Sist?licas
(PAS), M?dias (PAM) e Diast?licas (PAD) e Satura??o parcial de O2 (SPO2). Foram
utilizados no estudo 20 gatos h?gidos, com pesos variando entre dois e quatro kg e idades
entre tr?s e cinco anos, que foram submetidos aos procedimentos experimentais no per?odo
compreendido entre janeiro e fevereiro de 2010. A an?lise dos resultados demostraram que
houve diferen?a significativa (p<0,05) nas atividades s?ricas de ALT nos momentos T2 (30
minutos), T3 (60 minutos), T5 (12 horas) e T9 (28 dias); nas atividades s?ricas de AST no
momento T2; nas atividades s?ricas de FA nos momentos T2, T6 (7 dias) e T8 (21 dias),
sendo que, somente neste ultimo momento as dosagens do GP foram maiores que no GC; na
frequ?ncia card?aca no momento T1 (in?cio do experimento), sem causar qualquer
comprometimento ? sa?de dos animais. Nenhum dos animais apresentou m?dias acima dos
par?metros de normalidade. Os outros par?metros analisados n?o tiveram diferen?as
significativas, concluindo-se que a anestesia intravenosa total com uso de propofol em infus?o
cont?nua foi segura para conten??o de gatos em procedimentos incruentos, contribuindo assim
para maiores informa??es em rela??o ao uso desse f?rmaco nesses animais
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1188 |
| Date | 26 April 2011 |
| Creators | Ferreira, Janh Carlo de Amorim |
| Contributors | Botelho, Gilberto Garcia |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 7. REFER?NCIAS BIBLIOGR?FICAS ANDERS, B.B.; HOELZLER, M.G.; SCAVELLI, T.D.; FULCHER, R.P.; BASTIAN, R.P. Analysis of auditory and neurologic effects associated with ventral bulla osteotomy for removal of inflammatory polyps or nasopharyngeal masses in cats. Journal of American Veterinary Medical Association, v. 233, n.4, p. 580-585, 2008. ANDRESS, J.L.; DAY, T.K.; DAY, D.G. The effects of consecutive day propofol anesthesia on feline red blood cells. Veterinary Surgery, v.24, p.277-282. 1995. ARA?JO, I.C.; POMPERMAYER, L.G.; ANTUNES, F.; SOUZA, A.P.; LOPES, M.A.F. Analgesic effect, of butorphanol on somatic pain in cats anesthetized with propofol. Ci?ncia Rural, Santa Maria, v.31, n.1, p. 61-66, 2001. AUER, U.; MOSING, M. A clinical study of rocuronium in isoflurane - anaesthetized cats. Veterinary Anaesthesia and Analgesia, n.33, p. 224-228, 2006. BARATTA, M.T.; ZAYA, M.J.; WHITE, J.A.; LOCUSON, C.W. Canine CYP2B11 metabolizes an is inhibited by anesthetic agents often co-administered in dogs. Journal of veterinary Pharmacology and Therapeutics, v. 33, P. 50-55, 2009. BLEY, C.R., ROSS, M., PRICE, J., RUEZ-MELZER, K., BUCHHOLZ, J., POIRIER, V., KASER-HOTZ, B. Clinical assessment of repeated propofol-associated anesthesia in cats. Journal of American Veterinary Medicine Association. v.231, n.9, p. 1347-53, 2007. BRANSON, K.R. Injectable and Alternative Anesthetic Techniques. In: TRANQUILLI, W. J.; THURMON, J.C.; GRIMM, K.A. Lumb & Jones Veterinary Anesthesia and Analgesia. 4th ed. USA: Blackwell, p. 291-292, 2007. BRONDANI, T. B.; NATALINI, C.C.; SCHOSSLER, J.E.V.; FILHO, S.T.L.P.; BERTIN, A.P. Altera??es cardiovasculares de gatos submetidos ? toracotomia intercostal pr?medicados com associa??o de tramadol, butorfanol e atropina e anestesiados com propofol e halotano. Ci?ncia Rural, Santa Maria, v. 33, n. 5, p. 869-873, 2003. CHRISTOPHER, M.M.; WHITE, J.G.; EATON, J.W. Erythrocyte pathology and mechanisms of Heinz body-mediated hemolysis in cats. Veterinary Pathology, v. 27, n. 5. p. 299-310, 1990. CLEALE, R.M.; MUIR, W.W.; WASELAU, A.C.; LEHMANN, M.W.; AMODIE, D.M.; LERCHE, P. Pharmacokinetic and pharmacodynamics evaluation of propofol administered to cats in a novel, aqueous, nano-droplet formulation or as an oil-in-water macroemulsion. Journal or Veterinary Pharmacology and Therapeutics. v. 32, p. 436-445, 2009. CORR?A, M.A. Avalia??o cardiovascular e hipnoanalg?sica da associa??o de propofol e de cloridrato de remifentanil na manuten??o anest?sica por infus?o intravenosa cont?nua em felinos ap?s medica??o pr?-anest?sica com acepromazina. Botucatu. 143f. 38 Disserta??o (Mestrado) ? Faculdade de Medicina, Universidade Estadual Paulista, Botucatu. 2005. CORR?A, A.L.; OLESKOVICZ, N.; MORAES, A.N. ?ndice de mortalidade durante procedimentos anest?sicos: estudo retrospectivo (1996-2006). Ci?ncia Rural, v.39, n.9, p. 2519-2526, 2009. CULP, W.T.N; WEISSE, C.; KELLOG, M.E.; GORDON, I.K.; CLARKE, D.L.; MAY, L.R.; DROBATZ, K.J. Spontaneus hemoperitoneum in cats: 65 cases. Journal of American Veterinary Medicine Association, vol. 236, n.9, may 1, p.978-982, 2010 DANIEL, A.G.T.; LUCAS, S.R.R.; RECHE J?NIOR, A.; MONTEIRO, P.R.G.; RAMOS, D.; PIRES, C.G.; SINHORINI, I.L. Skin fragility syndrome in a cat with cholangiohepatitis and hepatic lipidosis. Journal of Feline Medicine and Surgery, n.12, p. 151-155, 2010. DAY, D. G. Diseases of the liver. In: SHERDING, R. G. The cat, Diseases and Clinical Management. 2nd ed., vol. 2, USA: Saunders, p. 1297-1340, 1994. DORIGNON, O.; OLESCOVICZ, N.; MORAES, A.N.; DALLABRIDA, A.L.; FLORES, F.N.; SOARES, A.V.; MORAES, T.J. Dexmedetomidina epidural em gatas submetidas ? oviariossalpingohisterectomia sob anestesia total intravenosa com propofol e pr? medicadas com Cetamina S (+) e Midazolam. Ci?ncia Rural, vol. 39, n. 3, p. 791-797, 2009. ECKERSALL, P.D. Proteins, proteomic and dysproteinemias. In: In: KANEKO, J.J.; HARVEY, J.W.; BRUSS, M.L. Clinical Biochemistry of Domestic Animals. 5th ed. USA: Academic Press, p. 117-155, 2008. EGGER; C.; MCCRACKIN, M.; HOFMEISTER, E.; TOUZOT-JOURDE, G.; ROHRBACH, B. Efficacy of preanesthetic intramuscular administration of ephedrine, for prevention of anesthesia induced hypotension in cats and dogs. Canine Veterinary Journal, vol. 50, p. 179-184, 2009. FANTONI, D.T.F.; CORTOPASSI, S. G.; BERNARDI, M.M. Anest?sicos intravenosos e outros parenterais. In: SPINOSA, H.S.; G?RNIAK, S.L.; BERNARDI, M.M. Farmacologia aplicada ? Medicina Veterin?ria. 3a ed. S?o Paulo: Guanabara Koogan, p. 117-128, 2002. FUTEMA, F. Avalia??o Pr? ? anest?sica In: CORTOPASSI, S.R.G.; FANTONI, D.T. Anestesia em c?es e gatos. 2a ed., S?o Paulo: Roca, p. 81, 2009. GLOWASKI, M.M.; WETMORE, L.A. Propofol: Application in Veterinary Sedation and Anesthesia. Clinical Techniques in Small Animal Practice, v. 14, n. 1, p.1-9, 1999. GRACE, S.F. Inflammatory liver disease (Hepatitis). In: NORSWORTHY, G.D.; CRYSTAL, M.A.; GRACE, S.F; TILLEY, L.P. The Feline Patient the Essential of Diagnosis and Treatment. 2nd ed., USA: Lippincot, p. 312-315, 2003. 39 GUANDOLINI, G.C. Enriquecimento ambiental para gatos dom?sticos (Felis catus): a import?ncia dos odores. Disserta??o de mestrado. Faculdade de Filosofia, Ci?ncias e Letras/USP. Ribeir?o Preto, 2009. JOHNSON, E.J.; SHERDING, R.G. Doen?as de F?gado e Trato Biliar. In: BIRCHARD, S.J.; SHERDING, R.G. Manual Saunders Cl?nica de Pequenos Animais. 3a ed. S?o Paulo: Roca, p. 765-838, 2008. KANEKO, J.J. Serum proteins and the dysproteinemias. In: KANEKO, J.J.; HARVEY, J.W.; BRUSS, M.L. Clinical Biochemistry of Domestic Animals. 5th ed. USA: Academic Press, p. 117-137, 1997. KERINS, A.M; BREATHNACH, R. The Respiratory System. In: CHANDLER, E.A.; GASKELL, C.J.; GASKELL, R.M. Feline Medicine and Therapeutics. 3rd ed., USA: Blackwell, p. 304, 2004. KOMATSU, T.; HONDA, K.; KUBOTA, A.; KITAZAWA, T.; HIRAGA, T.; TERAOKA, H. Molecular cloning and expression of cytochrome P450-2D6 in the liver of domestic cats. Journal of Veterinary Medicine Science. n. 72, v. 12, p. 1633-1666, 2010. LAPPIN, M.R. Segredos em Medicina Interna de Felinos. Porto Alegre: Artmed, p. 206- 207. 2004. LASCELLES, B.D.; COURT, M.H.; HARDIE, E.M.; ROBERTSON, S.A. Nonsteroidal anti-inflammatory drugs in cats: a review. Veterinary Anaesthesia and Analgesia, v. 34, p. 228-250, 2007. MARTINEZ, E.A. Anesthetic agents. In: BOOTHE, D.M. Small Animal Clinical Pharmacology and Therapeutics. USA: Saunders, p. 428, 2001. MEYER, D. J.; COLES, E. H.; RICH, L. J. Medicina de Laborat?rio Veterin?ria ? interpreta??o e diagn?stico. S?o Paulo: Roca. p.47-49, 1995. MASONE, F. Anest?sicos Injet?veis, in: FANTONI, D. T.; CORTOPASSI, S. R. G. Anestesia em C?es e Gatos. S?o Paulo: Roca. p.163-164, 2002. MUIR, W.W.; HUBBEL, J.A.E.; SKARDA, R.T.; BEDNARSKI, R.M.. Manual de Anestesia Veterin?ria, 3a ed. Porto Alegre: Artmed. p. 122-123, 255, 260. 2001. MUIR III, W.W.; SWANSON, C.R. Principles and Techniques of Anesthesia and Chemical Restraint. In: The cat, Diseases and Clinical Management. 2nd ed., vol. 1, USA: Saunders, p. 91-132, 1994. NATALINI, C.C. Teoria e T?cnicas em Anestesiologia Veterin?ria. Porto Alegre: Artmed. p. 72-74, 2007. NELSON, R.W.; COUTO, C.G. Medicina Interna de Pequenos Animais. S?o Paulo: Elsevier. p. 507-525, 2006. 40 PADDLEFORD, R. P. Manual de Anestesia em Pequenos Animais. 2?. ed. S?o Paulo: Roca. p. 60-63, 2001. PASCOE, P.J.; ILKIW, J.E; FRISCHMEIER, K.J. The effect of the duration of propofol administration on recovery from anesthesia in cats. Veterinary Anaesthesia and Analgesia, n. 33, p. 2-7, 2006. PERKOWSKI, S.Z. Sedation and anesthesia protocols for feline emergencies. In: NAVC Proceedings 2007, North American Veterinary Conference (Eds). Publisher: NAVC (www.tnavc.org). Internet Publisher: International Veterinary Information Service, Ithaca NY (www.ivis.org), Last updated: 13-Jan-2007. PIKOV, V.; BULLARA, L.; McCREERY, D.B. Intraspinal stimulation for bladder voiding in cats before and after chronic spinal cord injury. Journal Neural Engineering, n.4, v.4, p.356-368, 2007. POSNER, L.P.; ASAKAWA, M.; ERB, H.N. Use of propofol for anesthesia in cats with primary hepatic lipidosis- 44 cases (1995-2004). Journal of American Veterinary Medicine Association, Jun 15, n.232, v.12, p.1841-3, 2008. POSNER, L.P.; GLEENER, R.D.; ERB, H.N.; LUDDERS, J.W. Post anesthetic hyperthermia in cats. Veterinary Anaesthesia and Analgesia, n.34, p. 40-47, 2007. RECHE JUNIOR, A. A orbifloxacina no tratamento das cistites bacterianas em gatos dom?sticos. Ci?ncia Rural, Santa Maria, v. 35, n. 6, p. 1325-1330, 2005. REESE, M.J.; PATTERSON, E.V.; TUCKER, S.J.; DUBOVI, E.J.; DAVIS, R.D.; CRAWFORD, P.C.; LEVY, J.K. Effects of anesthesia and surgery on serologic responses to vaccination in kittens. Journal of American Veterinary Medicine Association, vol. 233, n.1, p. 116-121, 2008. RODRIGUES, R. Enzimas de uso na cl?nica veterin?ria. Dispon?vel em: <www6.ufrgs.br/bioqu?mica/posgrad/bta/enzimas_vet.pdf>Acesso em: 02/06/2009, 2005. ROELKE, M.E.; BROWN, M.A.; TROYER, J.L.; WINTERBACH, H.; WINTERBACH, C.; HEMSON, G.; SMITH, D.; JHONSON, R.C.; PECON-SLATTERY, J.; ROCA, A.L.; ALEXANDER, K.; KLEIN, L.; MARTINELLI, P.; KRISHNAMASU, K.; O?BRIEN, S.J. Pathological manifestations of Feline immunodeficiency v?rus (FIV) infection in wild African lions. Virology, n. 390, v. 1, p. 1-12, 2009. ROMAM, L.J.; MASTERS, B.S.S. Citocromos P450 e ?xido n?trico sintases. In: DEVLIN, T.M.; MICHELACCI,Y.M. Manual de Bioqu?mica com Correla??es Cl?nicas. 6?. ed. S?o Paulo, Blucher. p. 407-432, 2007. SELMI, A.L.; FIGUEIREDO, J.P.; MENDES, G.M; LAVOR, L.M.S.; MACHADO, P.M.L. Infus?o continua de propofol em gatos pr?-medicados com cetamina-midazolam. Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia. v. 57, n. 3, p. 295-299, 2005. 41 SHAH, S.S.; SASAKI, K.; HAYASHI, Y.; MOTOYAMA, S.; HELMI, A.R.; KHALIL, W.F.; SHIMODA, M. Inhibitory effects of Ketoconazole, Cimetidine and Erythromycin on hepatic CYP3A activities in cats. Journal of Veterinary Medicine Science, n. 71, p. 1151- 1159, 2009. SOUZA, SS. Efeito da dexmedetomidina, por via epidural ou infus?o continua intravenosa, em gatas anestesiadas com propofol e isoflurano e submetidas ? oviariossalpingohisterectomia. Disserta??o (mestrado), Universidade de S?o Paulo, Faculdade de Medicina Veterin?ria e Zootecnia, departamento de Cirurgia, 2006. TENNANT, B.C.; CENTER, S. A. Hepatic Function. In: KANEKO, J.J.; HARVEY, J.W.; BRUSS, M.L. Clinical Biochemistry of Domestic Animals. 5th ed. USA: Academic Press, p. 379-412, 2008. WIESSE, A.J.; LERCHE, P.; CLEALE, R.M.; MUIR, W.W. Investigation or escalating and large bolus doses of a novel, nano-droplet, aqueous 1% propofol formulation in cats. Veterinary Anaesthesia and Analgesia, v. 37, p. 250-257, 2010. WU,W.; YANG, C.; CHAI, C. Modulation of propofol on the effects of blood pressure and firing activity of related neurons in the medula. Chinese Journal of Phisiology, n. 52, v. 5, p. 358-364, 2009. |
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