Directed differentiation of mouse embryonic stem cells into neocortical output neurons

Description

During development of the neocortex, many diverse projection neuron subtypes are generated under regulation of cell-extrinsic and cell-intrinsic controls. One broad projection neuron class, corticofugal projection neurons (CFuPN), is the primary output neuron population of the neocortex. CFuPN axons innervate sub-cortical targets including thalamus, striatum, brainstem, and spinal cord.

Links & Downloads

1. Sadegh, Cameron. 2013. Directed differentiation of mouse embryonic stem cells into neocortical output neurons. Doctoral dissertation, Harvard University.
2. http://dissertations.umi.com/gsas.harvard:11064
3. http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181176

Tags

Neurosciences

Developmental biology

Biomedical engineering

Corticofugal projection neurons

Corticospinal motor neurons

Directed Differentiation

Embryonic stem cells

Neocortex

Synthetic modified RNA

Additional Fields

Identifer	oai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/11181176
Date	10 October 2015
Creators	Sadegh, Cameron
Contributors	Macklis, Jeffrey Daniel
Publisher	Harvard University
Source Sets	Harvard University
Language	en_US
Detected Language	English
Type	Thesis or Dissertation
Rights	open