Cell migration and invasion play a role in many physiological and pathological processes and
are therefore subject of intensive research efforts. Despite of the intensively investigated
biochemical processes associated with the migration and invasion of cells, such as cancer
cells, the contribution ofmechanobiological processes to themigratory capacity of cells as well
as the role of physical polymeric phase transitions is not yet clearly understood. Unfortunately,
these experiments are not very informative because they completely disregard the influence of
the three-dimensional cell environment. Despite this data situation, it was possible to
adequately demonstrate that there exists a direct mechanical interplay between cells and
theirmicroenvironment in both directions, where both elements can bemechanically altered by
one another. In line with these results, it has turned out that the mechanobiological molecular
processes through which cells interact with each other and additionally sense their nearby
microenvironment have an impact on cellular functions such as cellular motility. The
mechanotransduction processes have become the major focus of biophysical research
and thereby, diverse biophysical approaches have been developed and improved to
analyze the mechanical properties of individual cells and extracellular matrix environments.
Both, the cell mechanics and matrix environmentmechanics regulate the cellmigration types in
confined microenvironments and hence it seems to be suitable to identify and subsequently
present a common bidirectional interplay between cells and their matrix environment.
Moreover, hallmarks of the mechanophenotype of invasive cells and extracellular matrices
can be defined. This review will point out how on the one hand the intracellular cytoskeletal
architecture and on the other hand the matrix architecture contribute to cellular stiffness or
contractility and thereby determines the migratory phenotype and subsequently the
emergence of a distinct migration mode. Finally, in this review it is discussed whether
universal hallmarks of the migratory phenotype can be defined.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84420 |
| Date | 30 March 2023 |
| Creators | Mierke, Claudia Tanja |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2296-424X, 749830 |
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