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Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not

Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson’s disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:90411
Date04 April 2024
CreatorsFrank, Anika, Bendig, Jonas, Schniewind, Iñaki, Polanski, Witold H., Sobottka, Stephan B., Reichmann, Heinz, Akgün, Katja, Ziemssen, Tjalf, Klingelhoefer, Lisa, Falkenburger, Björn H.
PublisherMacmillan Publishers Limited, part of Springer Nature
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text
Rightsinfo:eu-repo/semantics/openAccess
Relation2045-2322, 1446, 10.1038/s41598-022-05117-x

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