Transdermal drug delivery systems (TDDSs) play important roles in therapy due to distinct
advantages over other forms and types of drug application. While common TDDS patches mainly
consist of polymeric matrices so far, inorganic carriers show numerous advantages such as high
mechanical stability, possible re-use and re-loading of drugs, and a broad chemical compatibility with
therapeutically relevant compounds and chemical enhancers. Mesoporous glasses can be prepared
in different monolithic shapes, and offer a particularly wide range of possible pore volumes, pore
diameters, and specific surface areas. Further, they show high loading capacities and favorable
physical, technical, and biological properties. Here, we explored for the first time monolithic SiO2-
based carriers as sustained release systems of therapeutic drugs. In an ideally stirred vessel as model
system, we systematically analyzed the influence of pore diameter, pore volume, and the dimensions
of glass monoliths on the loading and sustained release of different drugs, including anastrozole,
xylazine, imiquimod, levetiracetam, and flunixin. Through multilinear regression, we calculated
the influence of different parameters on drug loading and diffusion coefficients. The systematic
variation of the mesoporous glass properties revealed pore volumes and drug loading concentrations,
but not pore diameter or pore surface area as important parameters of drug loading and release
kinetics. Other relevant effectors include the occurrence of lateral diffusion within the carrier and
drug-specific properties such as adsorption. The structure–property relationships derived from our
data will allow further fine-tuning of the systems according to their desired properties as TDDS, thus
guiding towards optimal systems for their use in transdermal drug applications
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:86980 |
| Date | 31 August 2023 |
| Creators | Baumann, Frank, Paul, Theresa, Wassersleben, Susan, Regenthal, Ralf, Enke, Dirk, Aigner, Achim |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1184, 10.3390/pharmaceutics14061184 |
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