The study aims to replicate the previous found association of 5-HTTLPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14–21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyped for 5-HTTLPR/rs25531, grouped into SS/SLG/SLA/ LGLA/LGLG vs. LALA, and provided ratings on negative affect items, depression and anxiety (Patient-Reported Outcomes Measurement Information System) eight times a day over 4 days. Multilevel regression models did not reveal an association of 5-HTTLPR genotype and inertia of negative affect, nor associations with inertia of anxiety or depression. Inertia of negative affect seems not to be a psychological mechanism through which 5-HTTLPR acts on psychopathology.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89033 |
| Date | 19 March 2024 |
| Creators | Ollmann, Theresa M., Seidl, Esther, Venz, John, Pieper, Lars, Voss, Catharina, Hoyer, J., Kische, Hanna, Poppenhäger, Sophie R., Schiele, Miriam A., Domschke, Katharina, Beesdo-Baum, Katja |
| Publisher | Springer |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1435-1463, 10.1007/s00702-022-02459-8, info:eu-repo/grantAgreement/Bundesministerium für Bildung und Forschung/Internationale Graduiertenkollegs/01ER1303, 01ER1703//The epidemiology of functional and dysfunctional behavioral and psychological factors in health and disease (EBP) |
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