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Previous issue date: 2015-02-20 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Chronic sleep disorders are related to cognitive impairments and brain-derived neurotrophic factor (BDNF) alterations. However, the effects of acute sleep deprivation on BDNF levels and its relation with cognitive performance remains unknown. The objective was to investigate BDNF levels, cognitive performance and their relations in healthy subjects after acute sleep deprivation. In this study, nineteen sleep-deprived and twenty control subjects completed depression, anxiety and sleep quality questionnaires. Sleep deprived subjects spent a full night awake performing different playful activities to keep themselves awake. Attention, executive function and working memory (prefrontal cortex-dependent) were assessed with Stroop and Digit-span tests. Declarative memory (hippocampus-dependent) was assessed with Logical Memory test. Serum BDNF was measured by sandwich ELISA. Data were analyzed with independent samples T-test and curve estimation regressions. P<0.05 was deemed statistically significant. Our results show that the sleep-deprived group had higher BDNF levels and normal performance on attention, executive function and working memory. However, declarative memory was impaired. A sigmoidal relation between BDNF and Stroop Test scores was found, showing that the test performance was greater when the BDNF levels were at its peak. These data showed that increased BDNF could be related, at least in part, to the maintenance of normal prefrontal cognitive functions after sleep deprivation. This potential relation should be further investigated. / Transtornos cr?nicos do sono s?o relacionados a problemas cognitivos e altera??es no Fator Neurotr?fico Derivado do C?rebro (BDNF). No entanto, os efeitos da priva??o aguda do sono nos n?veis de BDNF e sua rela??o com o desempenho cognitivo permanecem incertos. O objetivo deste estudo foi investigar a rela??o entre os n?veis de BDNF no soro e desempenho cognitivo em sujeitos jovens saud?veis ap?s uma priva??o de sono aguda. Neste estudo, 19 sujeitos privados de sono e 20 controles completaram question?rios de depress?o, ansiedade e qualidade do sono. O grupo privado passou uma noite acordado realizando atividades l?dicas para se manter acordado. Aten??o, fun??o executiva e mem?ria de trabalho, dependentes do c?rtex pr?-frontal, foram analisados com os testes de Stroop e Span de d?gitos. Mem?ria declarativa, dependente do hipocampo, foi analisada com o teste de Mem?ria L?gica. O BDNF foi analisado por sandwich-ELISA. Os dados foram analisados com testes T para amostras independentes e regress?es por estimativa de curva. P<0.05 foi considerado estatisticamente significativo. Nossos dados mostraram que o grupo privado de sono apresentou maiores n?veis de BDNF no soro. Aten??o, fun??o executiva e mem?ria de trabalho n?o apresentaram diferen?a significativa entre grupos. No entanto, a mem?ria declarativa foi prejudicada em indiv?duos privados de sono. Foi encontrada uma rela??o sigmoidal entre o BDNF e o teste de Stroop, mostrando que o pico de performance neste teste est? relacionado com os n?veis mais altos de BDNF. Estes resultados mostram que o BDNF pode estar relacionado, em parte, com a manuten??o das fun??es cognitivas normais no c?rtex pr?-frontal ap?s a priva??o de sono. Esta rela??o em potencial deve ser mais investigada.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/6184 |
| Date | 20 February 2015 |
| Creators | Giacobbo, Bruno Lima |
| Contributors | Bromberg, Elke |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Biologia Celular e Molecular, PUCRS, Brasil, Faculdade de Bioci?ncias |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 8198246930096637360, 600, 600, 600, 600, 36528317262667714, -1634559385931244697, 2075167498588264571 |
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