Bacterial meningitis in dogs and cats is a rare disease associated with a high lethality
rate. The spectrum of causative bacteria includes a diverse set of gram positive, gram
negative and anaerobic species. Currently, no veterinary medicinal product is approved
for this indication in these species in Europe. The objective of this review was to
collect the available pharmacokinetic data for antibiotics approved in dogs and cats to
enable a preliminary analysis of their potential effectiveness for the treatment of bacterial
meningitis. This analysis yielded data for 13 different antibiotics in dogs and two in
cats. Additionally, data about frequently recommended cephalosporines not approved
in dogs and cats were included. The collected data was used to assess the potential
of the respective antibiotics to attain certain simple pharmacokinetic-pharmacodynamic
(PK-PD) indexes in the cerebrospinal fluid (CSF). A more sophisticated investigation
using modern methods was not possible due to the limited data available. For this
purpose, data about the sensitivity of four bacterial species commonly associated
with meningitis in dogs and cats to these antibiotics were included. The analysis
provided evidence for the potential effectiveness of ampicillin, doxycycline, enrofloxacin,
ceftriaxone and cefoxitin against bacteria frequently detected in bacterial meningitis in
dogs. Data were not available or insufficient for the assessment of several antibiotics,
including frequently recommended substances like metronidazole and trimethoprimsulphonamide.
Little evidence is available for the use of antibiotics in cats afflicted with
this disease, highlighting the need for further research to obtain data for evidence based
therapeutic recommendations.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84558 |
| Date | 04 April 2023 |
| Creators | Hertzsch, Robert, Richter, Angelika |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2297-1769, 769588 |
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