Serotonin (5-hydroxytryptamine or 5-HT) is an important neurotransmitter of the central
and peripheral nervous systems, predominantly secreted in the gastrointestinal tract, especially in
the gut. 5-HT is a crucial enteric signaling molecule and is well known for playing a key role in
sensory-motor and secretory functions in the gut. Gastroenteropathy is one of the most clinical
problems in diabetic patients with frequent episodes of hyperglycemia. Changes in 5-HT expression
may mediate gastrointestinal tract disturbances seen in diabetes, such as nausea and diarrhea. Based
on the double immunohistochemical staining, this study determined the variability in the population
of 5-HT-positive neurons in the porcine small intestinal enteric neurons in the course of streptozotocininduced
diabetes. The results show changes in the number of 5-HT-positive neurons in the examined
intestinal sections. The greatest changes were observed in the jejunum, particularly within the
myenteric plexus. In the ileum, both de novo 5-HT synthesis in the inner submucosal plexus neurons
and an increase in the number of neurons in the outer submucosal plexus were noted. The changes
observed in the duodenum were also increasing in nature. The results of the current study confirm
the previous observations concerning the involvement of 5-HT in inflammatory processes, and an
increase in the number of 5-HT -positive neurons may also be a result of increased concentration of
the 5-HT in the gastrointestinal tract wall and affects the motor and secretory processes, which are
particularly intense in the small intestines.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89087 |
| Date | 17 January 2024 |
| Creators | Bulc, Michal, Palus, Katarzyna, Calka, Jaroslaw, Kosacka, Joanna, Nowicki, Marcin |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 4564 |
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