Acute erythroleukemia (AEL) is a rare disease typically associated with a poor prognosis.
Themedian survival ranges between 3–9months frominitial diagnosis. Hypomethylating agents (HMAs)
have been shown to prolong survival in patients with myelodysplastic syndromes (MDS) and AML,
but there is limited data of their efficacy in AEL. We collected data from 210 AEL patients treated at
28 international sites. Overall survival (OS) and PFS were estimated using the Kaplan-Meier method
and the log-rank test was used for subgroup comparisons. Survival between treatment groups was
compared using the Cox proportional hazards regression model. Eighty-eight patients were treated with
HMAs, 44 front line, and 122 with intensive chemotherapy (ICT). ICT led to a higher overall response
rate (complete or partial) compared to first-line HMA (72% vs. 46.2%, respectively; p 0.001), but similar
progression-free survival (8.0 vs. 9.4 months; p = 0.342). Overall survival was similar for ICT vs. HMAs
(10.5 vs. 13.7months; p = 0.564), but patients with high-risk cytogenetics treated with HMA first-line lived
longer (7.5 for ICT vs. 13.3 months; p = 0.039). Our results support the therapeutic value of HMA in AEL.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89260 |
| Date | 25 January 2024 |
| Creators | Almeida, Antonio M., Prebet, Thomas, Itzykson, Raphael, Ramos, Fernando, Al-Ali, Haifa, Shammo, Jamile, Pinto, Ricardo, Maurillo, Luca, Wetzel, Jaime, Musto, Pellegrino, van de Loosdrecht, Arjan A., Joao Costa, Maria, Esteves, Susana, Burgstaller, Sonja, Stauder, Reinhard, Autzinger, Eva M., Lang, Alois, Krippl, Peter, Geissler, Dietmar, Falantes, Jose Francisco, Pedro, Carmen, Bargay, Joan, Deben, Guillermo, Garrido, Ana, Bonand, Santiago, Diez-Campelo, Maria, Thepot, Sylvain, Ades, Lionel, Sperr, Wolfgang R., Valent, Peter, Fenaux, Pierre, Sekeres, Mikkael A., Greil, Richard, Pleyer, Lisa |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 837 |
Page generated in 0.0016 seconds