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Previous issue date: 2015-12-21 / Otitis is defined as an inflammation, acute or chronic, of the ear canal and it?s considered one of the most common diseases in small animal practice. It possesses various perpetuating agents, bacteria and yeast being the most common. Treatment is based in the recognition of the primary causes and predisposing factors, and the resolution of secondary infections. A greater sensitivity in feline ear canal has also been shown, when compared to dogs. With this in mind, a product with the least possible active ingredients would be the ideal topical treatment in felines. However, the majority of available products combine antibiotics and antifungals, this combination not being necessary in all cases; for bacterial otitis, very few specific products exist, and some of them present a proven ototoxic potential. In face of this problem, the efficacy of a new formulation using levofloxacin for the specific treatment of bacterial otitis was made by the Farmacologia e Farmacometria sector of the LQEPV ? UFRRJ, using isopropylic alcohol as vehicle. Eighteen adult felines, belonging to the Laborat?rio de Quimioterapia Experimental em Parasitologia Veterin?ria (LQEPV-UFRRJ), diagnosed with bacterial otitis according to clinical signs (erythema, inflammation, pruritus, hyperpigmentation and secretions), as well as cytological exams and video-otoscopy, were chosen. Individual data was registered in specific formularies for comparison of pretreatment and post treatments evaluations. After the initial evaluation the animals were divided into three groups, according to treatment: in Group A or control (6 animals) a placebo (vehicle) was used; in Group B (6 animals) a formulation of levofloxacin 0, 5% was used; Group C (6 animals) a formulation of de levofloxacin 0, 5% + dexamethasone 0, 02% was used. In every case 0, 5 ml was applied to each ear, once a day for 15 consecutive days. Post treatment video-otoscopies were performed on day +21, and post treatment cytologies were performed on days +7, +14 and +21. The animals were always observed by the same evaluator, avoiding errors of concordance and checking for possible reactions to the product. None of the animals presented adverse reactions to the product during the treatment period, besides slight discomfort immediately after application. Animals from Group A continued with the same scores until the end of the experiment. Animals from Group B presented an initial clinical improvement, but some of them developed a fungal otitis as time passed. Animals from Group C presented a significant improvement since day +7, with no secondary alterations through time. It is demonstrated that a formulation of de levofloxacin + dexamethasone can be efficient and safe for the treatment of feline bacterial otitis / A otite ? definida como uma inflama??o, aguda ou cr?nica, do conduto auditivo e ? uma das doen?as mais frequentes na cl?nica de animais de companhia. Possui diversos agentes perpetuantes, sendo mais comuns as bact?rias e leveduras. O tratamento e baseado no reconhecimento de causas principais e fatores predisponentes, assim como a resolu??o de infec??es secund?rias. Tem sido relata uma sensibilidade maior nos condutos auditivos dos gatos, quando comparados com c?es. Deste modo, um produto com poucos ingredientes farmacologicamente ativos seria o tratamento t?pico ideal em felinos. No entanto, a maioria dos produtos para otite dispon?veis no mercado combina tanto antibi?ticos, como antif?ngicos, n?o sendo esta combina??o necess?ria em todos os casos; especificamente para otites bacterianas, existem poucos produtos espec?ficos, e muitos apresentam um potencial otot?xico j? comprovado. Perante este problema, foi avaliada a efic?cia de uma nova formula??o a utilizando levofloxacina para o tratamento espec?fico da otite bacteriana em felinos, o produto foi confeccionado pelo setor de Farmacologia e Farmacometria do LQEPV ? UFRRJ, utilizando como ve?culo ?lcool isoprop?lico. Foram selecionados 18 felinos adultos pertencentes ao Laborat?rio de Quimioterapia Experimental em Parasitologia Veterin?ria (LQEPV-UFRRJ), diagnosticados com otite bacteriana de acordo com sinais cl?nicos (eritema, inflama??o, prurido, hiperpigmenta??o e presen?a de secre??o), exame citol?gico e v?deo-otoscopia. Os dados individuais foram registrados em formul?rios espec?ficos para compara??o das avalia??es inicias e p?s-tratamento. Ap?s as avalia??es iniciais, os animais foram divididos em tr?s grupos experimentais: no grupo A, controle, seis animais utilizaram um Placebo (ve?culo); no grupo B, seis animais utilizaram a formula??o contendo Levofloxacina a 0,5%; e no grupo C, seis animais foram medicados com a associa??o de Levofloxacina 0,5% com dexametasona 0,02%. Em todos os casos foram instilados 0,5ml em ambas as orelhas uma vez por dia, durante 15 dias consecutivos. Exames vide-otosc?picos p?s-tratamento foram realizadas no dia +21, e citologias nos dias +7, +14 e +21. Os animais foram observados diariamente sempre pelo mesmo avaliador, evitando assim erros de concord?ncia e acompanhando poss?veis rea??es adversas ao produto. Nenhum animal apresentou rea??o adversa ao produto durante o per?odo de tratamento, al?m de incomodo no momento imediato ap?s a aplica??o. Os animais do grupo A continuaram com o mesmo score registrado no dia 0 at? finalizado o experimento. Os animais do grupo B apresentaram melhoria inicial, porem alguns deles desenvolveram otite f?ngica ao decorrer do tempo. J? os animais do grupo C apresentaram uma melhora significativa desde o dia +7, sem altera??es secund?rias no decorrer do experimento. Demostra-se assim que a associa??o de levofloxacina 0,5% com dexametasona 0,02% pode ser eficaz e segura para o tratamento da otite bacteriana em felinos
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1436 |
| Date | 21 December 2015 |
| Creators | Laguna, Ana?s Gabriela Villarreal |
| Contributors | Fernandes, Julio Israel, Moraes , Carina Martins de, Ramadinha, Regina Ruckert |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas), UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 7. REFER?NCIAS BIBLIOGR?FICAS AMARAL, R. C. et al. Microbiota ind?gena do meato ac?stico externo de gatos h?gidos. Ci?ncia Rural, v. 2, n. 3, p. 4441 ? 4445, 1998. doi: 10.1590/S0103-84781998000300015 ANGUS, J. C. Otic cytology in health and disease. Veterinary Clinics of North America: Small Animal Practic. v. 34, n. 2, p. 411?424. 2004. doi: 10.1016/j.cvsm.2003.10.005 ANGUS, J. C. Diseases of the Ear. In: CAMPBELL, K.I. Small Animal Dermatology Secrets. Philadelphia: Elsevier, 2004. p. 364- 393. ANGUS, J. C. Otitis Externa decision making using otic cytology. In: The North American Veterinary Conference, 2005; Orlando. The North American Veterinary Conference Proceedings, 2005, p. 810-811. BEALE, K. Feline Demodicosis: A consideration in the itchy or overgrooming cat. Journal of Feline Medicine and Surgery, v. 14, n. 3, p. 209?213, 2012. doi:10.1177/1098612X12439268. BELOVA, S. et al. Factors affecting allergen-specific IgE serum levels in cats. Canadian Journal of Veterinary Research, v. 76, n. 1, p. 45?51, 2012. doi: 10.5167/uzh-70624 BOWMAN, D. D.; HENDRIX, C. M.; LINDSAY, D. S.; BARR, S. C., Feline clinical parasitology. Iowa: Iowa State University Press, 2002. BRADLEY, J. S.; JACKSON, M. A. The Use of Systemic and Topical Fluoroquinolones. Journal of the American Academy of Pediatrics, v. 128, n. 4, p. 2011-1496, 2011. doi: 10.1542/peds.2011-1496 BRAGA, C. de A.; ARRUDA, A.F.O.; CASTRO, M.C.N.; SOARES A.M.B.; DIECKMANN, A.M. Perfil dos c?es e gatos dermatopatas atendidos na Policl?nica da Faculdade de Veterin?ria da UFF ? mar?o / 98 ? fevereiro / 2004, Niter?i, RJ. Revista Brasileira de Ci?ncias Veterin?rias, v. 17, n. 2, p. 73-76, 2010. CAIER?O, J. et al. Novos antimicrobianos: Realidade e Perspectivas. Newslab, v.66, p. 80- 90, 2004. CAMPBELL, K., 2013. Infection Control Strategies for Veterinary Hospitals. [Online] Dispon?vel em: https://www.zoetisus.com/Conditions/Pages/Dermatology/education-library/InfectionControl-VetHospitals.pdf [Acesso em 11 10 2015]. COLE, L. K. Otoscopic evaluation of the ear canal. Veterinary Clinics of North America Small Animal Practice, v. 34, n. 2, p. 397?410, 2004. doi: 10.1016/j.cvsm.2003.10.004 COLE, L. K. Anatomy and physiology of the canine ear. Veterinary Dermatology, v. 21, n. 2, p. 412?421, 2009. doi: 10.1111/j.1365-3164.2009.00849.x 59 COLE, L. K. Otitis Externa. In: GREENE, C. E. Infectious Diseases of the Dog and Cat . Missouri: Elsevier, 2012. p. 885-891. CRESPO, M.; ABARCA, M.; CABA?ES, F. Occurrence of Malassezia spp. in the external ear canals of dogs and cats with and without otitis externa. Medical Mycology, v. 40, n. 2, p. 115?121, 2002. doi: 10.1080/mmy.40.2.115.121 DAVIS, R.; BRYSON, H. M. Levofloxacin. Drugs, v. 47, n. 4, p. 677-700, 1994. doi: 10.2165/00003495-199447040-00008 ENGELEN, M.; DE BOCK, M.; HARE, J.; GOOSSENS, L. Effectiveness of an Otic Product Containing Miconazole, Polymyxin B and Prednisolone in the Treatment of Canine Otitis Externa: Multi-site Field trial in the US and Canada. International Journal of Applied Research in Veterinary Medicine, v. 8, n. 1, p. 21- 30, 2010. FOLEY, J. E. Prevention and Management of Infectious Diseases in Multiple-Cat Environments. In: GREENE, C. E. Infectious Diseases of the Dog and Cat . Missouri: Elsevier, 2012. p. 1130 - 1136. GINEL, P.; LUCENA, R.; RODRIGUEZ, J. A semiquantitative cytological evaluation of normal and pathological samples from the external ear canal of dogs and cats. Veterinary Dermatology, v. 13, n. 3, p. 151-156, 2002. doi: 10.1046/j.1365-3164.2002.00288.x GOTTHELF, L. N. Diagnosis and treatment of otitis media in dogs and cats. Veterinary Clinics of North America: Small Animal Practice, v. 34, n. 2, p. 469?487, 2004. doi: 10.1016/j.cvsm.2003.10.007 GRAHAM-MIZE, C. A.; ROSSER, E. J. Comparison of Microbial Isolates and Susceptibility Patterns From the External Ear Canal of Dogs With Otitis Externa. Journal of the American Animal Hospital Association, v. 40, n. 2, p. 102-108, 2004. doi: 10.5326/0400102 GRIFFIN, B. Population Wellness: Keeping Cats Physically and Behaviorally Healthy. In: LITTLE, S.: The Cat: Clinical Medicine and Management. Missouri: Elsevier, 2012. GRIFFIN, C. E. Otitis Techniques to Improve Practice. Clinical Techniques in Small Animal Practice, v. 21, n. 3, p. 96-105, 2006. doi: 10.1053/j.ctsap.2006.05.002 GRIFFIN, C. E. What?s causing this disastrous ear problem? In: Southern European Veterinary Conference & Congreso Nacional AVEPA, 2011; Barcelona. Proceedings of the Southern European Veterinary Conference, 2011, HARIHANA, H. et al. Aerobic bacteria from mucous membranes, ear canals, and skin wounds of feral cats in Grenada, and the antimicrobial drug susceptibility of major isolates. Comparative Immunology, Microbiology and Infectious Diseases, v. 34, n. 2, p. 129?134, 2011. doi: 0.1016/j.cimid.2010.05.001 HARVEY, R. G. H. J. &. D. A. G. Ear Diseases of the Dog and Cat.. London: Manson Publishing, 2001. 60 HAYNES, D. S.; RUTKA, J.; HAWKE, M.; ROLAND, P. Ototoxicity of Ototopical Drops: An Update. Otolaryngologic Clinics of North America, v. 40, n. 3, p. 669?683, 2004. doi:10.1016/j.otc.2007.03.010 HEINE, P. G. Anatomy of the Ear. Veterinary Clinics of North America: Small Animal Practice, v. 34, n. 2, p. 379?395, 2004. doi: 10.1016/j.cvsm.2003.10.003 HIGGINS, R.; GOTTSCHALK, M. Isolation of Staphylococcus felis from cases of external otitis in cats. Canadian Veterinary Journal, v. 32, n. 5, p. 312-313, 1991. HILL, P. et al. Survey of the prevalence, diagnosis and treatment of dermatological conditions in small animals in general practice. Veterinary Record, v. 158, n. 16, p. 533-539, 2006. doi: 10.1136/vr.158.16.533 HOBI, S. et al. Clinical characteristics and causes of pruritus in cats: a multicentre study on feline hypersensitivityassociated dermatoses. Veterinary Dermatology, v. 22, n. 5, p. 406?413, 2011. doi: 10.1111/j.1365-3164.2011.00962.x HORSPOOL, L. J. Novel Agents in the Treatment of Canine Otitis Externa.In: 69? Congresso Internazionale Multisala SCIVAC, 2011; Rimini. International Congress of the Italian Association of Companion Animal Veterinarians Proceeedings, p. 241-243. IGIMI, S. et al. Characterization of the most frequently encountered Staphylococcus sp. in cats. Veterinary Microbiology, v. 39, n. 3-4, p. 255-260, 1994. doi: 10.1016/0378-1135(94)90162-7 JACOBSON, L. Diagnosis and medical treatment of otitis externa in the dog and cat. Journal of the South African Veterinary Association , v. 73, n. 4, p. 162?170, 2002. doi: 10.4102/jsava.v73i4.581 KENNIS, R. A. Feline Otitis: Diagnosis and Treatment. Veterinary Clinics of North America: Small Animal Practice, v. 43, n. 1, p. 51?56, 2013. doi: 10.1016/j.cvsm.2012.09.009 KLAUSNER, J. Banfield Pet Hospital State of Pet Health 2011 Report, Portland : Banfield Pet Hospital. 2011. KLAUSNER, J. Banfield Pet Hospital State of Pet Health 2014 Report, Portland: Banfield Pet Hospital. 2014. KONEMAN, E.; ALLEN, S., 2008. Diagn?stico Microbiol?gico: Texto y Atlas en Color. 6ta ed. Buenos Aires: M?dica Panamericana. KOWALSKY, J. J. The microbial environment of the ear canal in health and disease. Veterinary Clinics of North America: Small Animal Practice, v. 18, n. 4, p. 743-754, 1988. doi: 10.1016/S0195-5616(88)50077-3 61 KUMAR, A.; SINGH, K.; SHARMA, A. Prevalence of Malassezia pachydermatis and other organisms in healthy and infected dogs ears. Israel Journal of Veterinary Medicine, v. 57, n. 4, 2002. LANZ, O.; WOOD, B. Surgery of the ear and pinna. Veterinary Clinics of North America: Small Animal Practice, v. 34, n. 2, p. 567?599, 2004. doi: 10.1016/j.cvsm.2003.10.011 LEY, J. M.; SEKSEL, K. Normal Behavior of Cats. In: LITTLE, S.: The Cat: Clinical Medicine and Management. Missouri: Elsevier. 2012. LORENZANA, L. C. Otitis externa: Etiopatogenia, diagn?stico y tratamiento. Virbac al d?a, v. 15, p. 1 ? 6, 2009. LUCAS, R.; CALABRIA, K. C.; PALUMBO, M. I. P. Otites. In: LARSSON, C. E.; LUCAS, R.: Tratado de Medicina Externa: Dermatologia Veterin?ria. S?o Caetano do Sul: Interbook, 2016. p. 779- 804. MARCHETTI, F.; VIALE, P. Current and Future Perspectives for Levofloxacin in Severe Pseudomonas aeruginosa Infections. Journal of Chemotherapy, v. 15, n. 4, p. 315-322, 2003. doi: 10.1179/joc.2003.15.4.315 MILLER, W. H.; GRIFFIN, C. E.; CAMPBELL, K. L., 2013. Muller and Kirk?s Small Animal Dermatology. 7ma ed. Missouri: Elsevier. MITTELMAN, H. Ototoxicity of ?ototopical? antibiotics: past, present, and future. Transactions - American Academy of Ophthalmology and Otolaryngology, v. 76, n. 6, p. 1432-1443, 1972. doi:10.1016/S0002-7154(72)30007-4 MORIELLO, K. A. Dermatology: Feline skin Diseases. In: LITTLE, S.: The Cat: Clinical Medicine and Management. Missouri: Elsevier, 2012. MURPHY, K. M. A Review of Techniques for the Investigation of Otitis Externa and Otitis Media. Clinical Techniques in Small Animal Practice, v. 16, n. 3, p. 236-241, 2001. doi: 0.1053/svms.2001.27601 NARDONI, S.; MANCIANTI, F.; RUM, A.; CORAZZA, M. Isolation of Malassezia species from healthy cats and cats with otitis. Journal of Feline Medicine and Surgery, v. 7, n. 3, p. 141-145, 2005. doi: 10.1016/j.jfms.2004.07.005 NJAA, B. L.; COLE, L. K.; TABACCA, N. Practical Otic Anatomy and Physiology of the Dog and Cat. Veterinary Clinics of North America: Small Animal Practice, v. 42, n. 6, p. 1109?1126, 2010. doi: 10.1016/j.cvsm.2012.08.011 NOBRE, M. et al. Malassezia pachydermatis e outros agentes infecciosos nas otites externas e dermatites em c?es. Ci?ncia Rural, v. 28, n. 3, p. 447-452, 1998. doi:10.1590/S0103-84781998000300016 62 NORSWORTHY, G. D., Otitis Externa. In: NORSWORTHY, G. D, et al.: The Feline Patient. Iowa: Blackwell Publishing, 2006. p. 218-219. OISHI, N.; TALASKA, A.; SCHACHT, J. Ototoxicity in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice, v. 42, n. 6, p. 1259?1271, 2012. doi:10.1016/j.cvsm.2012.08.005 ORT?NEZ, A.; VERDE, M.; NAVARRO, L.; REAL, L. Demodicosis Felina: a prop?sito de tres casos cl?nicos. Cl?nica Veterinaria de Peque?os Animales, v. 39, n. 3, p. 165-171, 2009. ISSN 1130-7064 PEREGO, R. et al. Prevalence of otitis externa in stray cats in northern Italy. Journal of Feline Medicine and Surgery, v. 16, n. 6, p. 483?490, 2014. doi:10.1177/1098612X13512119 POOLE, M. D. Bacterial resistance to quinolone otic drops is nearly Zero. ENT: Ear, Nose & Throat Journal, v. 86, n. 11, p. 13, 2007. RADLINSKY, M.; MASON, D. Diseases of the Ear. In: ETTINGER, S.J.; FELDMAN, E.C.: Textbook of Veterinary Internal Medicine. St. Louis: Saunders - Elsevier, 2010. p. 2839-2884. REAL, L.; ORTU?EZ, A.; VERDE, M.; NAVARRO , L. Otitis externa por Demodex cati. Cl?nica Veterinaria de Peque?os Animales, v. 30, n. 1, p. 47, 2010. ISSN 1130-7064 RODAN, I. Understanding the Cat and Feline-Friendly Handling. In: LITTLE, S.: The Cat: Clinical Medicine and Management. Missouri: Elsevier, 2012. ROLAND, P. S. et al. Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects. Otolaryngol Head Neck Surg, v. 130, n. 3, p. S57-S78, 2004. doi:10.1016/j.otohns.2003.12.008 ROSSER, E. J. Causes of otitis externa. Veterinary Clinics of North America: Small Animal Practice, v. 34, n. 2, p. 459?468, 2004. doi: 10.1016/j.cvsm.2003.10.006 ROSYCHUCK, R. A. W. Feline Ear Disease: So much more than *Ear Mites*. In: Southern European Veterinary Conference & Congreso Nacional AVEPA, 2008; Barcelona. Proceedings of the Southern European Veterinary Conference & Congreso Nacional AVEPA. ROSYCHUCK, R. A. W. Feline Ear Disease: So much more than ear mites. In: 36th World Small Animal Veterinary Congress WSAVA, 2011; Jeju, Korea. Proceedings of the 36th World Small Animal Veterinary Congress. p. 467-470. ROUGIER, S. et al. A comparative study of two antimicrobial /anti-inflammatory formulations in the treatment of canine otitis externa. Veterinary Dermatology, v. 16, n. 5, p. 299?307, 2005. doi: 10.1111/j.1365-3164.2005.00465.x RUTKA, J. Topical aminoglycosides? No. The case against using these agents in chronic ear disease. ENT: Ear, Nose & Throat Journal, v. 82, n. 1, p. 9-12, 2003. 63 RYCROFT, A.; SABEN, H. A Clinical Study of Otitis Externa in the Dog. Canadian Veterinary Journal, v. 18, n. 3, p. 64- 70, 1997. SCOTT, D. W.; MILLER, W. H.; ERB, H. N. Feline dermatology at Cornell University: 1407 cases (1988?2003). Journal of Feline Medicine and Surgery, v. 15, n. 4, p. 307?316, 2012. doi: 10.1177/1098612X12468922 SHIZUNOBU, I.; KAWAMURA, S.; TAKAHASHI, E.;MITUOKA, T. Staphylococcus felis, a New Species from Clinical Specimens. International Journal of Systemic Bacteriology, v. 39, n. 4, p. 373-377, 1989. doi: 10.1099/00207713-39-4-373 SHOKRI, H.; KHOSRAVI, A.: RAD, M.; JAMSHIDI, S. Occurrence of Malassezia Species in Persian and Domestic Short Hair Cats with and without Otitis Externa. Journal of Veterinary Medical Science, v. 72 n. 3, p. 293?29, 2010. doi: 10.1292/jvms.09-0421 SOTIRAKI, S. et al. Factors affecting the frequency of ear canal and face infestation by Otodectes cynotis in the cat. Veterinary Parasitology , v. 96, n. 4, p. 309?315, 2001. doi: 10.1016/S0304-4017(01)00383-1 SOUZA, C.P. de; SCOTT, F. B.; PEREIRA, M. J. S. Validade E Reprodutibilidade Da Otoscopia e d Reflexo Otopodal no Diagn?stico da Infesta??o por Otodectes Cynotis em c?es. Revista Brasileira de Parasitologia Veterin?ria, v. 13, n. 3, pp. 111-114, 2004. STRAIN, G. M. Aetiology, Prevalence and diagnosis of deafness in dogs and cats. British Veterinary Journal, v. 152, n. 1, p. 17- 36, 1996. doi: 10.1016/S0007-1935(96)80083-2 STRAIN, G. M. Canine Deafness. Veterinary Clinics of North America: Small Animal Practice, v. 42, n. 6, p. 1209?1224, 2012. doi: 10.1016/j.cvsm.2012.08.010 TAPIA, H.; R?OS, S. Otitis Externa en Perro, Revisi?n Bibliogr?fica. Revisi?n M?dica Peque?as Especies, (Revista Electr?nica) v. 4, p. 1-12, 2010. TILLEY, L. P.; SMITH, F. W. Blackwell's Five Minute Veterinary Consult: Canine and Feline. 4th ed. Iowa: Blackwell Publishing Professional, 2007. TORUN, B. et al. Efficacy of Ofloxacin Otic Solution Once Daily for 7 Days in the Treatment of Otitis Externa: A multicenter, Open-Label, Phase III Trial. Clinical Therapeutics, v. 26, n. 7, p. 1046- 1054, 2004. doi: 10.1016/S0149-2918(04)90176-2 TRUCCO, O., Aspectos Microbiol?gicos de las nuevas quinolonas: levofloxacina, sparfloxacina, trovafloxacina y grepafloxacina. Revista Chilena de Infectolog?a, v. 17, n.1, p. 67- 72, 2000. doi:10.4067/S0716-10182000000100009 VAN POUCKE, S. Ceruminous otitis externa due to Demodex cati in a cat. Veterinary Record, v. 149, n. 21, p. 651-652, 2001. doi: 10.1136/vr.149.21.651 64 VON EIFF, C.; PETERS, G. In-vitro activity of ofloxacin, levofloxacin and D-ofloxacin against staphylococci. Journal of Antimicrobial Chemotherapy, v. 38, n. 2, p. 259-263, 1996. doi: 10.1093/jac/38.2.259 WAISGLASS, S. Diagnostic Otology. In:Western Veterinary Conference, 2013; Las Vegas. Proceedings of the Western Veterinary Conference 2013. WEBSTER, J.; McGEE, T.; CARROL, R. Ototoxicity of gentamicin. Histopathologic and functional results in the cat. Transactions - American Academy of Ophthalmology and Otolaryngology, v. 74, p. 1155-1165, 1970. WEESE, J. S. The canine and feline skin microbiome in health and disease. Veterinary Dermatology, v. 24, n. 1, p. 137?e31, 2013. doi: 10.1111/j.1365-3164.2012.01076.x YOSHIDA, N.; NAITO, F.; FUKAT, T. Studies of Certain Factors Affecting the Microenvironment and Microflora of the External Ear of the Dog in Health and Disease. Journal of Veterinary Medical Science, v. 64, n.12, p. 1145?1147, 2002. doi : 10.1292/jvms.64.1145 |
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