Objective: We aimed at investigating the association of age-dependent IGF-I SDS with diabetes, dyslipidemia, hypertension, and heart diseases, in a large patient sample.
Background: IGF-I has been suggested to be associated with several diseases and a prognostic marker for the development of cardiovascular diseases and risk factors. The findings, though, have been inconsistent possibly due to the methodological factors.
Methods: We studied 6773 consecutive primary care patients, aged 18+ years, in a cross-sectional, epidemiological study in primary care, Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment study. All patients underwent a standardized clinical diagnostic and laboratory assessment. IGF-I levels were measured with an automated chemiluminescence assay system. We calculated the odds ratios (OR) for diseases in quintiles of IGF-I, and additionally analyzed the association of age-dependent IGF-I SDS with these conditions.
Results: After multiple adjustments for confounders, we found increased ORs for coronary artery disease in patients with high IGF-I. Women, but not men, with low IGF-I also showed increased ORs for coronary artery disease. Dyslipidemia was positively associated with IGF-I. Type 2 diabetes showed a curvilinear association with IGF-I SDS.
Conclusions: The findings suggest the existence of multiple and complex interactions between IGF-I and several health conditions. The complex nature of disease- and subgroup-specific associations along with the methodological factors can be held responsible for divergent findings in previous studies.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:26326 |
| Date | January 2008 |
| Creators | Schneider, Harald Jörn, Klotsche, Jens, Saller, Bernhard, Böhler, Steffen, Sievers, Caroline, Pittrow, David, Ruf, Günther, März, Winfried, Erwa, Wolfgang, Zeiher, Andreas M., Silber, Sigmund, Lehnert, Hendrik, Wittchen, Hans-Ulrich, Stalla, Günter Karl |
| Publisher | BioScientifica |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Source | European Journal of Endocrinology, Bd. 158 (2008), S. 153-161, ISSN: 0804-4643 |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 10.1530/EJE-07-0600 |
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