Different sampling devices for paper spray - mass spectrometry (PS - MS) were investigated to improve the assay’s simplicity and sensitivity over traditional approaches. In the first one, pressure-sensitive adhesive paper was used as both sampling tool to collect drug residues on surfaces and paper substrate in PS - MS analysis. This method showed a significant improvement in drug collection on surfaces leading to low nano-gram level detection limits. Other sampling device being investigated was snap-in solid-phase extraction column, which demonstrated the ability to detect trace amounts of drugs in plasma while allowed easy transportation and the use of PS - MS automated system.
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/15046341 |
| Date | 06 August 2021 |
| Creators | Chau Bao Nguyen (11178123) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/thesis/Paper_Spray_-_Mass_Spectrometry_Investigation_of_Sampling_Devices_for_Illicit_Drug_Detection_and_Quantification/15046341 |
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