Certain natural products, Ditamycin and Netropsin are considered as models of designing new DNA binding agents. A variety of DNA binding ligands were synthesized and accordingly characterized by different bioassays. In the series of azo-polyamide, it showed slight DNA binding affinity but has the properties of DNA photo-cleavage and recognition of mixed sequence. The carbohydrate-azo-polyamide series show the properties of DNA photo-cleavage and more effective in vitro experiment. In the quinoline series proves the attenuation effect for G-quadruplex stabilization which provides a novel strategy for development of G-quadruplex binding ligands.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0828112-143853 |
| Date | 28 August 2012 |
| Creators | Tung, Hung-Wei |
| Contributors | Po-Chiao Lin, Ming-Jung Wu, Chi-Wi Ong, Jeh-Jeng Wang |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0828112-143853 |
| Rights | user_define, Copyright information available at source archive |
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