Although human biomedical and physiological information is readily available, such information for great apes is limited. We analyzed clinical chemical biomarkers in serum samples from 277 wild- and captive-born great apes and from 312 healthy human volunteers
as well as from 20 rhesus macaques. For each individual, we determined a maximum of 33 markers of heart, liver, kidney, thyroid and pancreas function, hemoglobin and lipid metabolism and one marker of inflammation. We identified biomarkers that show differences between humans and the great apes in their average level or activity. Using the rhesus macaques as an outgroup, we identified human-specific differences in the levels of bilirubin, cholinesterase and lactate dehydrogenase, and bonobo-specific differences in the
level of apolipoprotein A-I. For the remaining twenty-nine biomarkers there was no evidence for lineage-specific differences. In fact, we find that many biomarkers show differences between individuals of the same species in different environments. Of the four lineagespecific
biomarkers, only bilirubin showed no differences between wild- and captive-born great apes. We show that the major factor explaining the human-specific difference in bilirubin levels may be genetic. There are human-specific changes in the sequence of the promoter and the protein-coding sequence of uridine diphosphoglucuronosyltransferase
1 (UGT1A1), the enzyme that transforms bilirubin and toxic plant compounds into water-soluble, excretable metabolites. Experimental evidence that UGT1A1 is down-regulated in the human liver suggests that changes in the promoter may be responsible for the human-specific increase in bilirubin. We speculate that since cooking reduces toxic plant compounds, consumption of cooked foods, which is specific to humans, may have resulted in relaxed constraint on UGT1A1 which has in turn led to higher serum levels of bilirubin in humans.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-176077 |
| Date | 10 August 2015 |
| Creators | Ronke, Claudius, Dannemann, Michael, Halbwax, Michel, Fischer, Anne, Helmschrodt, Christin, Brügel, Mathias, André, Claudine, Atencia, Rebeca, Mugisha, Lawrence, Scholz, Markus, Ceglarek, Uta, Thiery, Joachim, Pääbo, Svante, Prüfer, Kay, Kelso, Janet |
| Contributors | Universitätsklinikum, Institut für Laboratoriumsmedizin, Klinische Chemie und Molekulare Diagnostik, Max-Planck-Institut für Evolutionäre Anthropologie,, Universität Leipzig, Institut für Medizinische Informatik, Statistik und Epidemiologie (IMISE), Lola Ya Bonobo Sanctuary, “Petites Chutes de la Lukaya\", Réserve Naturelle Sanctuaire à Chimpanzés de Tchimpounga, Jane Goodall Institute, Conservation & Ecosystem Health Alliance (CEHA),, Makerere University, College of Veterinary Medicine, Animal Resources & Biosecurity, PLoS one, |
| Publisher | Universitätsbibliothek Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:article |
| Format | application/pdf |
| Source | PLoS one 2015, 10(8): e0134548 |
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