A significant goal in studies on learning and memory is to relate cellular plasticity to the modification of behaviour. The phenomenon of dual-process learning affords an ideal opportunity to explore the complexities inherent in establishing this relationship. Dual-process learning occurs when depression (habituation) and facilitation (sensitization) are expressed simultaneously within a neural network and compete to determine the behavioural outcome. A large body of literature is reviewed to define characteristics which are common across the neural networks that exhibit dual-process learning: depression occurs at loci early in the reflex pathway, upstream of the modulatory system necessary for the induction of facilitation. Consequently, depression not only competes directly with facilitation for the determination, of behavioural change (by serial and/or parallel expression), but depression also precludes the ongoing development and maintenance of sensitization (by serial induction). A mathematical model is presented to formally describe the nature of this competition and how this competition leads to the kinetics of dual-process learning. The tentacle withdrawal reflex of the snag Helix aspersa exhibits dual-process learning and was further investigated in this study. The neural circuit mediating tentacle withdrawal is described along with the nature and the location of plasticity which occurs within that circuit. In turn, plasticity at the cellular level is related, via the network level, to plasticity at the behavioural level. The data demonstrate the importance of localizing the sites of plasticity within a neural network in order to explain (1) how plasticity at a particular locus influences plasticity occurring elsewhere in the network and (2) how plasticity at different loci affect different aspects of behaviour.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.20844 |
| Date | January 1997 |
| Creators | Prescott, Steven A. |
| Contributors | Chase, Ronald (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Biology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001609754, proquestno: MQ44251, Theses scanned by UMI/ProQuest. |
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