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Transcriptional analysis of the role of CD8+ T lymphocytes in acute neural herpes simplex virus infection / David C. Tscharke.

Bibliography: leaves 141-182. / xi, 182, [36] leaves, [12] leaves of plates : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / The aim of this thesis is to analyse the molecular events associated with CD8+ T lymphocyte activity in HSV infected sensory ganglia. The role of CD8+ T cells in cytokine responses to ganglionic HSV infection is investigated, with particular reference to the Th1/Th2 paradigm and a known anti-viral mediator, IFN-[gamma]. A non-directed method of mRNA analysis is applied to HSV infected ganglia with the specific aim of identifying transcripts that may be associated with CD8+ T cell activity in the nervous system. / Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1997

Identiferoai:union.ndltd.org:ADTP/260269
Date January 1997
CreatorsTscharke, David C.
Source SetsAustraliasian Digital Theses Program
Languageen_US
Detected LanguageEnglish

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