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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Reflexive testosterone release in male mice : roles of genotype and sexual arousal /

James, Peter. January 2004 (has links)
Thesis (Ph. D.)--Lehigh University, 2005. / Includes vita. Includes bibliographical references (leaves 135-154).
2

Macrophage functions in mycobacterium lepraemurium-infected mice

夏國權, Ha, Kwok-kuen, David. January 1984 (has links)
published_or_final_version / Pathology / Doctoral / Doctor of Philosophy
3

Investigation of abnormal cardiac function in murine models of hypocontractility and hypercontractility

Tan, Ju Chiat, Graduate School of Biomedical Engineering, Faculty of Engineering, UNSW January 2006 (has links)
Heart failure has a significant impact on mortality and morbidity. Dilated cardiomyopathy (DCM) is the third most common cause of heart failure and the most common reason for heart transplantation. Familial DCM is known to be caused by mutations in the LMNA gene encoding lamins A and C. New methods to enhance cardiac contractility would be beneficial in the treatment or prevention of heart failure. The focus of this thesis was to evaluate the mechanisms of altered contractility in two mouse models: the LMNA knockout model (homozygous, Lmna-/-; heterozygous, Lmna+/-) generated by targeted deletion of the lmna gene, and the model of enhanced contractility due to cardiac alpha1A-adrenergic receptor (???1A-AR) overexpression (A1A1). Previous studies have found altered nuclear-desmin connections in lamin A/C deficient mice. It was proposed that these alterations result in ???defective force transmission???, which leads to DCM. Studies in this thesis have supported this hypothesis. Studies of isolated single cardiomyocytes from mice aged 4-6 weeks demonstrated abnormal cell morphology and contractile dysfunction in Lmna-/- cardiomyocytes, while Lmna+/- cells showed no overt phenotype. Excitation-contraction coupling experiments and forcecalcium studies in skinned fibers excluded altered calcium kinetics as a primary cause of DCM in this model, but there was evidence of reduced sarcomere numbers and reduced sarcomere lengths as a contributor to reduce force generation in Lmna-/- and Lmna+/- mice. Previous in vivo studies showed that A1A1 mice had enhanced contractility with the absence of hypertrophy. Studies on isolated single cardiomyocytes from A1A1 mice aged 8-12 weeks showed reduced contractility in the absence of ???1A-AR stimulation, but an exaggerated response to ???1A-AR stimulation. In contrast isolated isovolumic Langendorff perfused A1A1 hearts without ???1A-AR stimulation replicated the enhanced contractility observed in vivo. These studies are consistent with down-regulation of contractility due to the hyperactivity of the overexpressed ???1A-AR in vivo, which only becomes evident in isolated cells without ???1A-AR stimulation due to the loss of functional receptor numbers during isolation. Sufficient spontaneously active ???1A-ARs are preserved in the isolated Langendorff heart preparation to ensure maximum contractility driven by increase calcium release.
4

The effects of risperidone, an atypical antipsychotic, on the reeler mutant mouse, a potential model of schizophrenia

Goode, Amanda K. January 1900 (has links) (PDF)
Thesis (M.A.)--University of North Carolina at Greensboro, 2006. / Title from PDF title page screen. Advisor: Walter Salinger; submitted to the Dept. of Psychology. Includes bibliographical references (p. 76-86).
5

The effects of risperidone, an atypical antipsychotic, on the reeler mutant mouse, a potential model of schizophrenia

Goode, Amanda K. January 1900 (has links) (PDF)
Thesis (M.A.)--University of North Carolina at Greensboro, 2006. / Title from PDF title page screen. Advisor: Walter Salinger; submitted to the Dept. of Psychology. Includes bibliographical references (p. 76-86).
6

Macrophage functions in mycobacterium lepraemurium-infected mice /

Ha, Kwok-kuen, David. January 1984 (has links)
Thesis--Ph. D., University of Hong Kong, 1984.
7

The functional interaction of mouse secretin and angiotensin II receptors

Wong, Ka-yan, Karen, 黃嘉欣 January 2010 (has links)
published_or_final_version / Biological Sciences / Master / Master of Philosophy
8

Characterization of the mouse myosin va cargo-binding domain

歐穗欣, Au, Sui-yan. January 2002 (has links)
published_or_final_version / Biochemistry / Master / Master of Philosophy
9

Modelling human genetic disorders in mice

Migdalska, Anna Marta January 2012 (has links)
No description available.
10

Epigenetic regulation of imprinted loci in the mouse

McEwen, Kirsten Rose January 2011 (has links)
No description available.

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