Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic addiction." By using unbiased genetic tools to functionally probe oncogenic addiction, we can identify cancer dependencies and characterize aspects of oncogenic signaling.
Identifer | oai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/11169824 |
Date | 10 October 2015 |
Creators | Shao, Diane Donghui |
Contributors | Hahn, William C. |
Publisher | Harvard University |
Source Sets | Harvard University |
Language | en_US |
Detected Language | English |
Type | Thesis or Dissertation |
Rights | open |
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