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Testung einer aktiven Tau-Immunisierung zur Verminderung der Motoneuronendegeneration im Tau-transgenen Mausmodell

Immunotherapy for Alzheimer\''s disease has emerged as a promising approach for clearing pathological tau protein conformers. To explore this kind of treatment we tested an active immunization with pseudo-phosphorylated tau fragments in P301L tangle model mice that develop neuronal tau aggregates as observed in frontotemporal dementia and Alzheimer’s disease.
We found that an immunization reduces neurodegeneration in α-motor neurons in the spinal cord and slows progression of the tangle-related behavioral phenotype. Performance on behavioral assays correlated with tau pathology at the corresponding spinal cord level. Interestingly, a slowed progression of these tauopathy related characteristics were only seen in mice that received a specific immunization with pseudo-phosphorylated tau fragments, not in animals that received a non-specific activation of the immune system.
An immunization witch pseudo-phosphorylated tau fragments may be a valuable therapeutic option in targeting one of the major hallmarks of Alzheimer’s disease and frontotemporal dementia.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:13623
Date08 October 2015
CreatorsSchaller, Marie-Catherine
ContributorsHolzer, Max, Arendt, Thomas, Gertz, Hermann-Josef, Uniklinikum Leipzig
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageGerman
Detected LanguageEnglish
Typedoc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text
Rightsinfo:eu-repo/semantics/openAccess

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