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Previous issue date: 2014-03-28 / A esp?cie Opuntia f?cus-indica (L.) Mill ? uma cact?cea pertencente ao ecossistema Caatinga e apresenta em sua composi??o qu?mica flavonoides, ?cido galactur?nico e a??cares. Foram desenvolvidos diferentes extratos vegetais hidroglic?licos (EHG001 e EHG002) e hidroetan?licos posteriormente liofilizados (EHE001 e EHE002), dentro os quais o EHE002 teve sua composi??o fitoqu?mica preliminar investigada por cromatografia em camada delgada e observada a predomin?ncia de flavonoides. Foram preparadas diferentes formula??es na forma de emuls?es com o Sodium Polyacrylate (and) Hydrogenated Polydecene (and) Trideceth-6 (Rapithix? A60) e com o Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7 (Sepigel? 305) e em gel com o Sodium Polyacrylate (Rapithix? A100). O estudo de avalia??o sensorial foi realizado utilizando a metodologia check-all-thatapply. N?o foram verificadas diferen?as significativas entre as notas atribu?das ?s formula??es, por?m, foi observada prefer?ncia pelas formuladas com o 1,5% de Rapithix? A100 e com 3,0% de Sepigel? 305. Essas e a formula??o com 3% de Rapithix? A60 foram aditivadas com 1% do extrato hidroglic?lico (EHG001) e submetidas aos testes de estabilidades preliminar e acelerada. No estudo de estabilidade acelerada, as amostras foram estocadas em diferentes temperaturas durante 90 dias. As caracter?sticas organol?pticas, determina??o do valor de pH e comportamento reol?gico foram avaliados. Ao final do estudo, as emuls?es com 3,0% de Sepigel? 305 e 3% de Rapithix? A60 foram consideradas est?veis com caracter?sticas pseudopl?sticas e tixotr?picas. A efic?cia cl?nica hidratante das formula??es contendo 3,0% de Sepigel? 305 aditivadas com 1 e 3% do EHG001 foi realizada por meio do m?todo da capacit?ncia (Corneometer?) e da avalia??o da perda de ?gua transepidermal - TEWL (Tewameter?). Observou-se que a formula??o com 3% do EHG001 apresentou efic?cia hidratante frente ao ve?culo e ao solvente extrator ap?s 5 horas e as emuls?es contendo 1 e 3% do extrato apresentaram efeito barreira at? 4 horas reduzindo a perda de ?gua transepidermal. / Opuntia f?cus
-
indica
(L.)
Mill is a cactacea presents in the Caatinga ecosystem
and shows in its chemical c
omposition flavonoids, galacturonic acid and sugars.
Different hydroglicolic (EHG001 and EHG002) and hydroethanolic subsequently
lyophilized (EHE001 and EHE002) extracts were developed. The EHE002 had his
preliminary phytochemical composition investigated
by thin layer chromatography
(TLC) and we observed the predominance of flavonoids. Different formulations were
prepared as emulsions with Sodium Polyacrylate (and) Hydrogenated Polydecene
(and) Trideceth
-
6 (Rapithix? A60), and Polyacrylamide (and) C13
-
14 I
soparaffin (and)
Laureth
-
7 (Sepigel? 305), and gel with Sodium Polyacrylate (Rapithix? A100). The
sensorial evaluation was conducted by check
-
all
-
that
-
apply method. There were no
significant differences between the scores assigned to the formulations, howe
ver, we
noted a preference for those formulated with 1,5% of Rapithix? A100 and 3,0% of
Sepigel? 305. These and the formulation with 3% Rapithix? A60 were tested for
preliminary and accelerated stability. In accelerated stability study, samples were
stored
at different temperatures for 90 days. Organoleptic characteristics, the pH
values and rheological behavior were assessed.
T
he emulsions formulated with 3,0%
of Sepigel? 305 and 1,5% of Rapithix?
A60
w
ere stable with pseudoplastic and
thixotropic
behavior
. The moisturizing clinical efficacy of the emulsions containing 3,0%
of Sepigel? 305
containing
1 and 3% of EHG001 was performed using the capacitance
method (Corneometer?) and transepidermal water lost
?
TEWL evaluation
(
Tewameter?). The results showed t
hat the formulation with 3% of EHG001
increased
the
skin moisturizing against the vehicle and the extractor solvent formulation after five
hours. The formulations containing 1 and 3% of EHG001
increased
skin barrier effect
by reducing transepidermal water
loss up to four hours after application.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/19365 |
| Date | 28 March 2014 |
| Creators | Damasceno, Gabriel Azevedo de Brito |
| Contributors | 12835182870, http://lattes.cnpq.br/5782539548696465, Ostrosky, Elissa Arantes, 16276603805, http://lattes.cnpq.br/8787499230023565, Silva, V?nia Rodrigues Leite e, 11887816852, http://lattes.cnpq.br/0737387413540260, Langassner, Silvana Maria Zucolotto, Ferrari, M?rcio |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM CI?NCIAS FARMACEUTICAS, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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