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Previous issue date: 2008 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / O presente estudo teve por objetivo avaliar a correlação entre a atividade
de macrófagos e a apoptose nas formas polares da hanseníase. Para tal foram
analisadas amostras constituídas de 29 biopsias de pele de pacientes com as
formas polares da hanseníase. Para a medida da atividade macrofágica e da
apoptose, utilizou-se o método imunohistoquímico, visando os marcadores
lisozima, CD68, iNOS (para atividade de macrófago) e caspase 3 (para apoptose).
No tratamento estatístico, foi utilizado o teste não paramétrico de Mann-Whitney e
a Correlação linear de Spearman. Os resultados obtidos sugerem que a taxa de
apoptose sofre influência direta da atividade macrofágica nas lesões de pacientes
TT, contudo nas lesões LL, notou-se que outros fatores devem estar induzindo a
morte celular programada, possivelmente o TGF-β. / The present study had for objective to evaluate the correlation between the
activity of macrophage and the apoptosis in the polar forms of the leprosy. For
such constituted samples of 29 biopsies of patients' skin were analyzed with the
polar forms of the leprosy. For the measure of the activity of macrophage and of
the apoptosis, the method immunohistochemistry was used, seeking the markers
lysozyme, CD68, iNOS (for activity of macrophage) and caspase 3 (for apoptosis).
In the statistical treatment, it was used the test non parametric of Mann-Whitney
and the lineal Correlation of Spearman. Do the obtained results suggest that the
apoptosis rate suffers direct influence of the activity of macrophages in the lesions
of patient TT, however in the lesions what was LL, noticed other factors they must
it is inducing the programmed cellular death, possibly TGF-β.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufpa.br:2011/4804 |
| Date | 23 July 2008 |
| Creators | LIMA, Luiz Wagner de Oliveira |
| Contributors | QUARESMA, Juarez Antônio Simões |
| Publisher | Universidade Federal do Pará, Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, UFPA, Brasil, Instituto de Ciências Biológicas |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFPA, instname:Universidade Federal do Pará, instacron:UFPA |
| Rights | info:eu-repo/semantics/openAccess |
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