Background and Purpose: Flow diversion is increasingly used as an endovascular
treatment for intracranial aneurysms. In this retrospective multicenter study, we analyzed
the safety and efficacy of the treatment of intracranial, unruptured, or previously treated
but recanalized aneurysms using Flow Re-Direction Endoluminal Device (FRED) Jr with
emphasis on midterm results.
Materials and Methods: Clinical and radiological records of 150 patients harboring 159
aneurysms treated with FRED Jr at six centers between October 2014 and February
2020 were reviewed and consecutively included. Clinical outcome was measured by
using the modified Rankin Scale (mRS). Anatomical results were assessed according to
the O’Kelly-Marotta (OKM) scale and the Cekirge-Saatci Classification (CSC) scale.
Results: The overall complication rate was 24/159 (16%). Thrombotic-ischemic events
occurred in 18/159 treatments (11%). These resulted in long-term neurological sequelae
in two patients (1%) with worsening from pre-treatment mRS 0–2 and mRS 4 after
treatment. Complete or near-complete occlusion of the treated aneurysm according to
the OKM scale was reached in 54% (85/158) at 6-month, in 68% (90/133) at 1-year, and
in 83% (77/93) at 2-year follow-up, respectively. The rates of narrowing or occlusion of
a vessel branch originating from the treated aneurysm according to the CSC scale were
11% (12/108) at 6-month, 20% (17/87) at 1-year, and 23% (13/57) at 2-year follow-up,
respectively, with all cases being asymptomatic.
Conclusions: In this retrospective multicenter study, FRED Jr was safe and effective in
the midterm occlusion of cerebral aneurysms. Most importantly, it was associated with
a high rate of good clinical outcome.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84340 |
| Date | 27 March 2023 |
| Creators | Jesser, Jessica, Alberalar, Nilüfer D., Kizilkilic, Osman, Saatci, Isil, Baltacioglu, Feyyaz, Özlük, Enes, Killer-Oberpfalzer, Monika, Vollherbst, Dominik F., Islak, Civan, Cekirge, Saruhan H., Bendszus, Martin, Möhlenbruch, Markus, Koçer, Naci |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1664-2295, 722183 |
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