The ability of tissues and cells to move and rearrange is central to a broad range of diverse
biological processes such as tissue remodeling and rearrangement in embryogenesis, cell
migration in wound healing, or cancer progression. These processes are linked to a solidlike
to fluid-like transition, also known as unjamming transition, a not rigorously defined
framework that describes switching between a stable, resting state and an active, moving
state. Various mechanisms, that is, proliferation and motility, are critical drivers for the (un)
jamming transition on the cellular scale. However, beyond the scope of these fundamental
mechanisms of cells, a unifying understanding remains to be established. During
embryogenesis, the proliferation rate of cells is high, and the number density is
continuously increasing, which indicates number-density-driven jamming. In contrast,
cells have to unjam in tissues that are already densely packed during tumor
progression, pointing toward a shape-driven unjamming transition. Here, we review
recent investigations of jamming transitions during embryogenesis and cancer
progression and pursue the question of how they might be interlinked. We discuss the
role of density and shape during the jamming transition and the different biological factors
driving it.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84416 |
| Date | 30 March 2023 |
| Creators | Blauth, Eliane, Kubitschke, Hans, Gottheil, Pablo, Grosser, Steffen, Käs, Josef A. |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2296-424X, 666709 |
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