Previous research suggests that the efficacy of Ertapenem, a carbapenem antibiotic administered intravenously, is related to a patient’s body mass index. Using an existing physiologically based pharmacokinetic (PBPK) model for Ertapenem, we constructed a least squares inverse problem to determine an optimal dose for males with varying body weights and heights. The criteria for an optimal dose was based upon pharmacokinetic and pharmacodynamic (PK/PD) parameters calculated for a male with a body height of 175 cm and a weight of 72 kg. We also adjusted dosing intervals to ensure that effective concentration of drug between doses was the same for all males regardless of BMI.
Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:honors-1638 |
Date | 01 May 2019 |
Creators | Jewett, Bethany |
Publisher | Digital Commons @ East Tennessee State University |
Source Sets | East Tennessee State University |
Detected Language | English |
Type | text |
Format | application/pdf |
Source | Undergraduate Honors Theses |
Rights | Copyright by the authors., http://creativecommons.org/licenses/by-nc-nd/3.0/ |
Page generated in 0.0019 seconds