Background: Dyslipidemia is strongly associated with the development of hypertension.
In our previous study, it was shown that elevated TC, LDL-c, and non-HDL-c were
associated with the prevalence of hypertension in Chinese men, whereas the relationship
between HDL-c and hypertension shifted from no association to a positive association
after adjusting for the BMI. To further accumulate epidemiological evidence in Asian
women, this study aimed to investigate the relationship between lipid profile and
prevalence of hypertension in Chinese adult women.
Methods: This is a cross-sectional study including 54,099 Chinese women aged>20
years at 32 health screening centers in 11 cities from 2010-2016. The original data were
obtained from DATADRYAD database (www.datadryad.org). Besides, the overall women
were classified into non-hypertensive and hypertensive groups based on baseline blood
pressure levels. Differences between the two groups were examined by Man-Whitney test
or Chi-square test. Spearman’s correlation coefficient was employed to evaluate the
correlation between systolic blood pressure (SBP), diastolic blood pressure (DBP) and
lipid profiles. Multivariate logistic regression was performed to estimate the relationship
between different lipid levels and the prevalence of hypertension. Odds ratios (ORs) and
95% confidence intervals (CIs) indicated the risk of lipid and hypertension. Bayesian model
(BN) model was constructed to further assess the relationship between baseline
characteristics and the prevalence of hypertension, as well as the importance of each
variable for the prevalence of hypertension.
Results: Compared to the non-hypertensive population, the hypertensive population was
older, and had the higher body mass index (BMI), total cholesterol (TC), low-density
lipoprotein cholesterol (LDL-c), serum creatinine (Scr), fasting blood glucose (FPG), blood
urea nitrogen (BUN), alanine aminotransferase (ALT), aspartate aminotransferase (AST),
and non-high-density lipoprotein cholesterol (non-HDL-c), but HDL-c and the presence
concerning the family history of diabetes were lower. Multivariate logistic regression
analysis revealed that TC, LDL-c, and non-HDL-c showed a positive trend with hypertension risk (p for trend < 0.05) whereas TC and HDL-c were not significantly associated
with hypertension prevalence. Moreover, each 1 mg/dl increase in TC, LDL, and non-HDL
hypertension prevalence increased by 0.2% [1.002 (1.000-1.003)], 0.2% [1.002 (1.000-
1.004)], and 0.2% [1.002(1.001-1.004)], respectively. BN suggested that the importance of
age, BMI, FPG, non-HDL-c on the prevalence of hypertension was 52.73%, 24.98%, 11.22%,
and 2.34%, respectively.
Conclusion: Overall, in Chinese adult women, TC, LDL-c and non-HDL-c levels were higher
and HDL-c level was lower in the hypertensive population, whereas TG did not differ
significantly from the non-hypertensive population. Meanwhile, TC, LDL-c, and non-HDL-c
were positively associated with prevalence of hypertension, and HDL-c was negatively
associated with prevalence of hypertension but became nonsignificant after full adjustment
for variables. Moreover, BN model suggested that age, BMI, FPG, and non-HDL-c had a
greater effect on the development of hypertension.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:87496 |
| Date | 19 October 2023 |
| Creators | Deng, Guizhi, Li, Yunjie, Cheng, Wenke |
| Publisher | Frontiers Media S.A. |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 904237, 10.3389/fendo.2022.904237 |
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