Magister Pharmaceuticae - MPharm / Cardiovascular diseases (CVDs) such as ischaemic heart diseases, heart failure and stroke
remain a major cause of death globally. Various deep-rooted factors influence CVD
development; these include but are not limited to elevated blood lipids, high blood pressure,
obesity and diabetes. A considerable number of proteins are involved directly and indirectly in
the transport, maintenance and elimination of plasma lipids, including high and low-density
lipoprotein cholesterol (HDL-C and LDL-C). There are several mechanisms involved in the
removal of LDL particles from systemic circulation. One such mechanism is associated with
the gene that encodes proprotein convertase subtilisin/kexin type 9 (PCSK9), which has
become an exciting therapeutic target for the reduction of residual risk of CVDs. Currently,
statins are the mainstay treatment to reduce LDL-C, and a need exists to further develop more
effective LDL-C-lowering drugs that might supplement statins. This study was aimed at
contributing to the generation of knowledge regarding the effect of niacin in reducing LDL
levels through PCSK9 interaction.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/7931 |
| Date | January 2020 |
| Creators | Ngqaneka, Thobile |
| Contributors | Obikeze, Kenechukwu, Chauke, Chesa Gift, Magwebu, Zandisiwe Emilia |
| Publisher | University of Western Cape |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Rights | University of Western Cape |
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