It is controversial whether lifestyle-induced weight loss (LIWL) intervention provides
long-term benefit. Here, we investigated whether the degree of weight loss (WL) in a controlled
LIWL intervention study determined the risk of prediabetes and recurrence of metabolic syndrome
(MetS) during a 5-year follow-up. Following LIWL, 58 male participants (age 45–55 years) were
divided into four quartiles based on initial WL: Q1 (WL 0–8.1%, n = 15), Q2 (WL 8.1–12.8%, n = 14),
Q3 (WL 12.8–16.0%, n = 14), and Q4 (WL 16.0–27.5%, n = 15). We analyzed changes in BMI, HDL
cholesterol, triglycerides (TGs), blood pressure, and fasting plasma glucose (FPG) at annual follow-up
visits. With a weight gain after LIWL between 1.2 (Q2) and 2.5 kg/year (Q4), the reduction in BMI
was maintained for 4 (Q2, p = 0.03) or 5 (Q3, p = 0.03; Q4, p < 0.01) years, respectively, and an increase
in FPG levels above baseline values was prevented in Q2–Q4. Accordingly, there was no increase in
prediabetes incidence after LIWL in participants in Q2 (up to 2 years), Q3 and Q4 (up to 5 years). A
sustained reduction in MetS was maintained in Q4 during the 5-year follow-up. The present data
indicate that a greater initial LIWL reduces the risk of prediabetes and recurrence of MetS for up to
5 years.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:87853 |
| Date | 02 November 2023 |
| Creators | Zimmermann, Silke, Vogel, Mandy, Mathew, Akash, Ebert, Thomas, Rana, Rajiv, Jiang, Shihai, Isermann, Berend, Biemann, Ronald |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 3060 |
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